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UnknownHeme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Not available
S-EPMC6355645 | biostudies-literature
ProteomicsTop-down proteomics of membrane proteoforms from HeLa cells and mouse hippocampus
Comprehensive characterization of membrane proteins at the level of proteoforms in complex biological samples by top-down mass spectrometry is of vital importance in revealing their precise functions. Based on a novel membrane protein separation technology, we obtained a dataset of membrane proteofo...
ORGANISM(S): Homo Sapiens Mus Musculus 
2023-02-08 | PXD039949 |
ProteomicsAffinity peptide ligands: New tools for chasing non-canonical N-phosphoproteome
Protein N-phosphorylation enrichment is faced with great difficulties due to the intrinsic instability of the N-P bond, which has seriously hindered its biological function unraveling. Current methods for N-phosphopeptides enrichment are challenging to fulfil high selectivity for all types of N-phos...
ORGANISM(S): Homo Sapiens Escherichia Coli Mus Musculus 
2024-12-12 | PXD058797 |
ProteomicsProteoform Imaging by Combining MALDI MSI and High-sensitivity Top-down Proteomics
Spatially resolved characterization of proteoforms has great potential to significantly advance our understanding of physiological and disease mechanisms. However, it faces challenges regarding throughput and coverage. Herein, we developed a robust method for high-throughput proteoform imaging (HTPi...
ORGANISM(S): Mus Musculus 
2024-12-03 | PXD058552 |
ProteomicsA multiplex fragment ion-based method for accurate proteome quantification
We developed a multiplex pseudo-isobaric dimethyl labeling (m-pIDL) method for proteome quantification to extend the capacity of the fragment ion-based method to 6-plex by one-step dimethyl labeling with several millidalton and dalton mass differences between precursor ions and enlarging the isolati...
ORGANISM(S): Homo Sapiens Escherichia Coli 
2019-01-22 | PXD012457 |
ProteomicsOrthogonal Ionic Liquid-based Extraction Strategy Enables Amyloid-Specific Profiling of the Aggregate Proteome
Amyloid deposits are key pathological features of neurodegenerative diseases, yet their structural heterogeneity coupled with a stable β-sheet fibrillar architecture makes them extremely insoluble and difficult to isolate. Through systematic screening and molecular dynamics simulations, we identifie...
ORGANISM(S): Mus Musculus 
2025-10-17 | PXD069689 |
ProteomicsBis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell microspheres enabled comprehensive analysis of N-phosphoproteome
Herein, bis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell silica microspheres (SiO2@DpaZn) were tailored for N-phosphopeptide enrichment at pH 7.7. Contributed by the coordination bonding between Zn(II) and phosphate groups with the KD value of 13.14 μM, N-phosphopeptides could be capt...
ORGANISM(S): Escherichia Coli 
2020-02-07 | PXD017423 |
ProteomicsBis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell microspheres for analysis of N-phosphoproteome-
Herein, bis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell silica microspheres (SiO2@DpaZn) were tailored for N-phosphopeptide enrichment at pH 7.7. Contributed by the coordination bonding between Zn(II) and phosphate groups with the KD value of 13.14 μM, N-phosphopeptides could be capt...
ORGANISM(S): Homo Sapiens 
2020-08-22 | PXD021067 |
UnknownSurfactant Therapy for Respiratory Distress Syndrome in High- and Ultra-High-Altitude Settings.
Not available
S-EPMC8930851 | biostudies-literature
ProteomicsUrine proteomics identifies biomarkers for plaque stability in patients with carotid atherosclerosis.
Carotid atherosclerotic plaques refer to the formation of fibrofatty lesions in the walls of the carotid arteries. Unstable carotid atherosclerotic plaques are more likely to lead to the occurrence of stroke events. The aim of this study is to search for biomarkers that can be used to identify the s...
ORGANISM(S): Homo Sapiens 
2025-05-25 | PXD064282 |
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