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ProteomicsIntegrative genomic and proteomic analysis of response of Lactobacillus casei str. Zhang to glucose limitation
Nutrient starvation is an important survival challenge for bacteria during industrial production of functional foods. Lactobacilli are increasingly being used as probiotics in functional foods. As next-generation sequencing technology has greatly advanced, we performed integrative proteomic and geno...
ORGANISM(S): Lactobacillus casei str. Zhang 
2018-02-08 | PXD006643 | Pride
Lactobacillus casei str. zhang  lace of glucose 
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
ProteomicsCombination of multi-enzyme digestions and C-TAILS approach for deep screening of C-terminome
Protein C-termini study is still a challenging task and far behind its counterpart N-termini study. The identification of C-termini is often hampered by low ionization response in MS and fewer efficient enrichment methods existing. We previously optimized the C-TAILS (C-terminal amine-based isotope ...
ORGANISM(S): Escherichia coli 
2017-11-24 | PXD004275 | Pride
Protein c-termini C-tails Multi-enzyme Scii 
Proteomicsc-JUN interacte with NuRD complex to regulate chromatin remodeling
detect c-JUN interaction proteins in humanembryonic stem cells
ORGANISM(S): Homo Sapiens 
2023-12-28 | PXD048153 |
ProteomicsSystematic optimization of C-TAILS approach for deep screening of C-terminomics
It is well known that protein C-termini play important roles in various biological processes, and thus the precise characterization of C-termini is essential for fully elucidating protein structure and understanding protein functions. Although many efforts have been made in the fields during the lat...
ORGANISM(S): Escherichia coli 
2015-09-15 | PXD002409 | Pride
Protein c-termini Acetylation Scii 
TranscriptomicsMKL1-dependent tenascin-C transcription
The aim of the experiment is to investigate whether megakaryoblastic leukemia factor-1 (MKL1) induces tenascin-C in normal mammary epithelial HC11 and tumor mammary epithelial 4T1 cell lines, as well as to identify other genes that are transcriptionally regulated by MKL1. For this purpose, we compar...
ORGANISM(S): Mus musculus 
2011-06-10 | E-MEXP-3232 | biostudies-arrayexpress
TranscriptomicsA global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
Genome-wide location analysis of transcription factor of c-Myc and Max was conducted using RenLab Hu6K array in Daudi cells. In comparison, the GWLA was also done for general transcription factor RNA polymerase II and TAF1, and sequence specific transcription factor E2F1 in the same cell line. Keyw...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-2542 | biostudies-arrayexpress
ProteomicsLys-C/Arg-C, a New Enzyme Combination for Next-Generation Proteomics
Today, the most widely used bottom-up proteomics studies necessitate a proteolysis step prior to MS analysis. Trypsin is often the best protease in choice due to its high specificity and MS-favored proteolytic products. Trypsin has been challenged for its low cleavage efficiency at Lys-X bonds, and ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-24 | PXD009797 | Pride
Lys-c / arg-c / trypsin / dia / mass spectrometry 
ProteomicsReversible Lysine Derivatization Enables High Specificity of Arg-C Digestion Using Trypsin
Bottom-up proteomics approach has become an important strategy in diverse areas of biological research, and the enzymatic digestion is essential for this technology. Endopeptidase Arg-C catalyzing the hydrolytic cleavage of peptide bonds C-terminal to arginine could be an important protease in botto...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-01-04 | PXD007994 | Pride
Proteomics Arg-c Trypsin Lys-c Citraconylation Lc-ms/ms 
TranscriptomicsExpression Profiling of Caenorabditis elegans tdp-1 loss-of-function mutant
Transactive response DNA-binding protein of 43 kDa (TDP-43), a heterogeneous nuclear ribonucleoprotein (hnRNP) with diverse activities, is a common denominator in several neurodegenerative disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Orthologs...
ORGANISM(S): Caenorhabditis elegans 
2012-02-21 | E-GEOD-34113 | biostudies-arrayexpress
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