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UnknownCryo-EM of the human insulin receptor ectodomain in complex with an insulin analog with truncated B chain and enlongated A chain
Not available
EMPIAR-10736 | biostudies-other
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Murine UPLC-MS/MS assays)

Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression remains unknown. Here we showed, through a longitudinal analysis on two cohorts involving four UK centers, that basel...

2023-06-12 | MTBLS6894 | MetaboLights
MetabolomicsAirway Dysbiosis Accelerates Lung Function Decline in Chronic Obstructive Pulmonary Disease (Human UPLC-MS/MS assays)

Progressive decline in lung function is a hallmark of chronic obstructive pulmonary disease (COPD). Although airway dysbiosis occurs in COPD, whether it contributes to disease progression remains unknown. Here, through a longitudinal analysis on 181 COPD individuals from two large cohorts involvi...

2023-06-12 | MTBLS5423 | MetaboLights
TranscriptomicsTranscriptomic analysis of TLR4 pathways in a murine model of chronic pulmonary inflammation and carcinogenesis
Toll like receptor 4 (TLR4), an innate immunity gene, is involved in responses to several pulmonary agonists including endotoxin (LPS; Poltorak et al.,1998), ozone (O3 ,Kleeberger et. al., 2001), Pseudomonas aeruginosa (Faure et al, 2004), and hyperoxia (Zhang et al, 2005). TLR4 appears to partially...
ORGANISM(S): Mus musculus 
2009-12-12 | E-GEOD-8504 | biostudies-arrayexpress
UnknownClinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Not available
S-EPMC6366813 | biostudies-literature
UnknownLong-term treatment with human immunoglobulin for antisynthetase syndrome-associated interstitial lung disease.
Not available
S-EPMC11678789 | biostudies-literature
TranscriptomicsExpression data from glioblastoma cells after ZFHX4 or CHD4 suppression.
ZFHX4 and CHD4 suppression independently shift tumor initiating cells out of a stem like state and toward a differentiated morphology. After gene suppression via transduction of a lentivirally mediated shRNA construct, RNA was extracted 3 and 5 days later and was hybridized on Affymetrix microarrays...
ORGANISM(S): Homo sapiens 
2014-01-16 | E-GEOD-52363 | biostudies-arrayexpress
Transcriptomicstranscriptome analysis of differentially expressed genes in the harlequin (hlq) mutant
Plant growth and development is continuous and modular, a combination that allows morphogenesis by controlled cell division and elongation and serves to facilitate plantsM-bM-^@M-^Y adaptations to changing environments. Plasticity is achieved through integration of external and internal signals to ...
ORGANISM(S): Arabidopsis thaliana 
2014-06-03 | E-GEOD-45806 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fat biopsies from subcutaneous adipose tissue from unrelated individuals - a systems genetics approach implicates USF1, FADS3 and other causal candidate genes for familial combined hyperlipidemia
Assessment of mRNA expression levels in fat biopsies from subcutaneous adipose tissue from unrelated individuals. Experiment Overall Design: Subcutaneous adipose tissue from 70 unrelated individuals.
ORGANISM(S): Homo sapiens 
2009-09-18 | E-GEOD-17170 | biostudies-arrayexpress
GenomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [Bisulfite-Seq]
Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxie...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35854 | biostudies-arrayexpress
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