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ProteomicsLysine acetylproteome profiling reveals key acetylated proteins involved in heat shock response in the sea cucumber Apostichopus japonicus
Intestine of a total of 9 idividuals was sampled. The individuals were collected from 3 groups: Control (C), Heat stress 6h (HS6h) and Heat stress 48h (HS48h).After protein extraction,trypsin digestion and enrichment of Lys-acetylated peptides, the eluted peptides was applied with LC-MS/MS detection...
ORGANISM(S): Stichopus japonicus (Sea cucumber) 
2019-11-12 | PXD013929 | Pride
Intestine Heat stress Apostichopus japonicus Acetylproteome 
ProteomicsIdentification of missing proteins in the proteome atlas of multiple healthy human tissues
We re-analyzed the deep proteome atlas of 29 paired healthy human from the published paper (Wang, Dongxue, et al. Molecular systems biology 15.2 (2019)) to identify missing proteins.
ORGANISM(S): Homo sapiens (Human) 
2020-11-17 | PXD021391 | Pride
Chpp Open-pfind Missing proteins Mutiple tissues 
ProteomicsApostichopus japonicus intestine LC-MS/MS
In this study, we applied iTRAQ techniques to investigate the global protein expression profile under an acute short-term (48 h) heat stress. A total of 3,432 proteins were identified, and 127 heat stress-response proteins were detected.
ORGANISM(S): Stichopus japonicus (Sea cucumber) 
2016-02-17 | PXD002660 | Pride
Intestine Apostichopus japonicus Lc-ms/ms 
ProteomicsOnline Microfluidics Mass Spectrometry Reveals Molecular Responses of Bacterial Filamentation and Inhibition Methods of Drug Resistant Bacteria
Filamentation is one of the self-saving responses and a survival strategy of bacteria in the circumstance of antibiotics. Understanding the molecular mechanism of filamentation can lead to the development of new inhibition methods for antibiotic-resistant bacteria. In this work, we develop an online...
ORGANISM(S): Escherichia Coli 
2021-02-26 | PXD024394 |
ProteomicsMolecular Responses During Bacterial Filamentation Induced by Antibiotics
Bacterial filamentation is one of the most important bacterial SOS responses to antibiotic drugs and contributes to the development of antimicrobial resistance. Understanding the mechanism of the bacterial SOS response is crucial to control the development of antibiotic-resistant bacteria. We uncove...
ORGANISM(S): Escherichia Coli 
2023-01-04 | PXD039235 |
ProteomicsZASP：A Robust Method for Proteomics Sample Preparation
ZASP can effectively remove SDS, SDC, TritonX-100 and other denaturing reagents. • ZASP has short precipitation time, high protein recovery and identification number. • Compared with acetone and SP3 precipitation method, ZASP has remarkable performance. • ZASP is particularly suitable for complex sa...
ORGANISM(S): Homo Sapiens Mus Musculus 
2023-05-16 | PXD042276 |
ProteomicsDIA proteomic of serum samples for the exploration of the pathological mechanism of Obstetric Antiphospholipid syndorme
Obstetric Antiphospholipid syndrome (OAPS) is a multisystem disorder characterized by thrombosis and/or recurrent fetal loss. In this study, we aim to further explore the pathological mechanism of OAPS. Herein, we carried out quantitative proteomic analysis of serum samples from OAPS patients and he...
ORGANISM(S): Homo Sapiens 
2023-09-25 | PXD045626 |
ProteomicsProteomic analysis revealed the potential role of MAGE-D2 in therapeutic targeting of triple-negative breast cancer
Triple negative breast cancer (TNBC) is one of the most aggressive molecular subtypes in breast cancer. Due to the lack of effective therapeutic targets, the clinical outcomes for TNBC patients remain poor. Here, we performed an integrated proteomic analysis including bioinformatic analysis of prote...
ORGANISM(S): Homo Sapiens 
2023-03-07 | PXD040645 |
ProteomicsVessel-on-a-Chip Coupled Proteomics Reveal Pressure-Overload-Induced Vascular Remodeling
We developed a vessel-on-a-chip to mimic both physiological and pathological stretch, along with a mouse model of hypertension. We applied proteomics analysis to investigate the changes in vascular smooth muscle cells using the vessel-on-a-chip system and changes in hypertensive mice.
ORGANISM(S): Mus Musculus 
2024-11-08 | PXD057724 |
ProteomicsDeep proteomic analysis of circulating large/small extracellular vesicle enriched fraction based on data-independent acquisition mass spectrometry
Proteins in the plasma/serum mirror an individual’s physiology. Circulating extracellular vesicle (EVs) proteins constitute a large portion of the plasma/serum proteome. Thus, deep and unbiased proteomic analysis of circulating plasma/serum extracellular vesicles holds promise for discovering diseas...
ORGANISM(S): Homo Sapiens 
2023-06-26 | PXD043290 |
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