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The cytosolic DNA sensor cyclic GMP-AMP (cGAMP) synthetase (cGAS) has emerged as a fundamental component fueling the anti-pathogen immunity. Because of its pivotal role in initiating innate immune response, the activity of cGAS must be tightly fine-tuned to maintain immune homeostasis in antiviral r...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-02-22 | PXD024088 | Pride
Extracellular vesicles (EVs) are attracting increasing interest with their intrigue role in intercellular communications. Protein phosphorylation in EVs is of great importance for understanding intercellular signaling processes. However, the study of EV phosphoproteomics is impeded by their relative...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD020861 | Pride
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Homo sapiens 

In this study, the physiological phenotyping, RNA sequencing, widely targeted metabolomics, and phytohormone profiling were used to examine the responses of maize seedlings to progressive PEG-induced osmotic stress and their recovery after PEG removal. 

2026-09-26 | MTBLS15230 | MetaboLights
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