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ProteomicsChemical labeling for fine mapping of IgG N-glycosylation by ETD-MS
Immunoglobulin G (IgG), which contains four subclasses (IgG1-4), is one of the most important class of glycoproteins in immune system. Because of its importance in immune system, a steady increase of interest in developing IgG as biomarker or biotherapeutic agents for the treatment of diseases has b...
ORGANISM(S): Homo sapiens (Human) 
2019-08-26 | PXD014713 | Pride
Chemical labeling Igg Glycosylation Glycopeptides Electron transfer dissociation (etd) mass spectrometry 
ProteomicsSAPT, a fast and efficient approach for simultaneous profiling of protein N- and C-terminome
Protein termini play pivotal roles in various biological processes. Although a series of terminomic strategies have been proposed for the analysis of protein N-termini or protein C-termini separately, few can analyze both ends of proteins at the same time. Herein, we developed a workflow, termed Sim...
ORGANISM(S): Homo sapiens (Human) 
2021-07-29 | PXD024573 | Pride
Human Protein termini Hela cell 
ProteomicsUltrafast and Chemoselective Biotinylation of Living Cell Surface for Time-Resolved Surfaceome Analysis - final
Cell surface proteins participate in many important biological processes such as cell-to-cell interaction, signal transduction, cell adhesion, and protein transportation. In-depth study of the cell surface protein group is of great significance. Nevertheless, detection and analysis of the surfaceome...
ORGANISM(S): Homo Sapiens 
2024-07-06 | PXD053733 |
ProteomicsHST-MRM-MS: A Novel High-Sample-Throughput Multiple Reaction Monitoring Mass Spectrometric Method for Multiplex Absolute Quantitation of Hepatocellular Carcinoma Serum Biomarker
Absolute quantification of clinical biomarkers by mass spectrometry (MS) has been challenged due to low sample-throughput of current multiple reaction monitoring (MRM) methods. For this problem to be overcome, in this work, a novel high-sample-throughput multiple reaction monitoring mass spectrometr...
ORGANISM(S): Homo Sapiens 
2020-02-23 | PXD040708 |
ProteomicsNAPT, an unbiased approach for sequential analysis of protein N- and C- terminome
Robust analysis of both protein N- and C-termini can reveal novel N- and C-degrons that modify protein stability and shape the eukaryotic proteome. Herein, we designed a workflow, termed LysargiNase-assisted Analysis of Protein N- and C-Terminome (NAPT) by sequential and selective separating N- and ...
ORGANISM(S): Homo Sapiens 
2022-04-11 | PXD030791 |
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
ProteomicsFluoroTRAQ: Quantitative Analysis of Protein S-nitrosylation through Fluorous Solid-phase Extraction Combining with iTRAQ by Mass Spectrometry
S-nitrosylation is an important post-translational modification which occurs on cysteine in organisms. S-nitrosylation regu-lates signal transduction in many cell processes and aberrant S-nitrosylated (SNO-) proteins are closely related to cardiovas-cular and neurological diseases. However, quantita...
ORGANISM(S): Homo Sapiens 
2020-07-30 | PXD020657 |
ProteomicsA lncRNA from the FTO locus acts as an inhibitor of the m6A writer complex and p53 tumor suppression signaling
control RNA and FTO-IT1 RNA and their interacting proteins were pulled down by biotin-streptavidin beads to see the interacting protein of FTO-IT1 RNA.
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD041053 | Pride
Fto-it1 Prostate cancer 
ProteomicsHigh throughput quantitative analysis of site-specific N-glycosylation reveals glyco-signatures for diagnosis of liver disease
Glycosylation influences diverse life processes and changes in pathological processes. The glycoproteomic has been recognized as a hot area to screen markers as altered glycosylation is a universal feature of cancer cells. However, the high throughput screening of glycosylation markers from a large ...
ORGANISM(S): Homo Sapiens 
2021-07-16 | PXD027379 |
Proteomicsone step carboxyl group isotopic labeling for quantitative analysis of N-glycopeptide by Mass Spectrometry
Glycosylation is one of the most common and important post-translational modifications. Quantitative analysis of intact N-glycopeptides is critical to understand the role of protein glycosylation in physiological and pathological processes. In this work, we developed a novel approach called methylam...
ORGANISM(S): Homo Sapiens 
2020-08-25 | PXD021104 |
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