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TranscriptomicsTranscription profiling of SrcR388A/Y527F or SrcD386N/Y527F stably transfected SYF cells serum-starved overnight and then treated with imidazole 5 mM for 1 h or 12 reveals that the protein tyrosine kinase Src R388A mutant can be rescued in live cells using the small molecule imidazole
SrcR388A/Y527F or SrcD386N/Y527F stably transfected SYF cells were serum-starved overnight and then treated with imidazole 5 mM for 1 h or 12 h. RNeasy Miniprep column (Qiagen) was used to prepare total RNA from each treatment group. All samples were run in commercial arrays from Affymetrix,
ORGANISM(S): Mus musculus 
2007-12-12 | E-GEOD-4043 | biostudies-arrayexpress
ProteomicsOptimization of ultracentrifugation-based method to enhance the purity and proteomic profiling depth of plasma-derived extracellular vesicles and particles
Circulating extracellular vesicles and particles (EVPs) are being investigated as potential biomarkers for early cancer detection, prognosis, and disease monitoring. However, the suboptimal purity of EVPs isolated from peripheral blood plasma has posed a challenge of in-depth analysis of the EVP pro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD052726 | Pride
Extracellular vesicles and particles (evps)  early cancer detection  biomarkers  proteomics 
UnknownGlobal research trends on the links between NfL and neurological disorders: A bibliometric analysis and review.
Not available
S-EPMC11327529 | biostudies-literature
ProteomicsHistone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity
Histone H3 monoaminylations at glutamine(Q) 5 represent an important family of epigenetic markers in neurons that play critical roles in the mediation of permissive gene expression (1, 2). We previously demonstrated that H3Q5 serotonylation(ser) and dopaminylation(dop) are catalyzed by the Transglut...
ORGANISM(S): Homo sapiens (Human) 
2024-10-10 | PXD053788 | Pride
Tgm2 Bidirectionally controls h3 monoaminylation dynamics Which Facilitate neural rhythmicity. In turn A single enzyme 
Proteomics5HT - Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3
we provide evidence for a new class of histone posttranslational modification (PTM): serotonylation.
ORGANISM(S): Homo sapiens (Human) 
2018-12-19 | PXD008106 | Pride
Posttranslational modification Ptm Serotonylation. 
ProteomicsTumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis
Development of effective therapies against brain metastasis is currently hindered by limitations in our understanding of the molecular mechanisms driving it. Here we define the contributions of tumour-secreted exosomes to brain metastatic colonization and demonstrate that pre-conditioning the brain ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD015210 | Pride
Tumour exosomal cemi brain metastasis 
GenomicsFunctional dissection of QTL-region affecting fat-deposition
Functional dissection of QTL-region affecting fat-deposition
ORGANISM(S): Sus scrofa 
2018-10-15 | E-MTAB-1434 | biostudies-arrayexpress
TranscriptomicsCellular source and mechanisms of high transcriptome complexity in the mammalian testis (RNA-Seq cells)
Understanding the extent of genomic transcription and its functional relevance is a central goal in genomics research. However, detailed genome€wide investigations of transcriptome complexities in major mammalian organs  and  their  underlying  cellular sources, transcriptional mechanisms, and func...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-43717 | biostudies-arrayexpress
TranscriptomicsCellular source and mechanisms of high transcriptome complexity in the mammalian testis (RNA-Seq organs)
Understanding  the  extent  of  genomic  transcription  and  its  functional  relevance  is  a  central  goal  in  genomics research. However, detailed genome‐wide investigations of transcriptome complexities in major mammalian organs  and  their  underlying  cellular  sources,  transcriptional  mec...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-43721 | biostudies-arrayexpress
ProteomicsTissue- and plasma-derived exosomal protein biomarkers define multiple human cancers
There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of exosomes in 426 human samples from tissue explants (TE), plasma and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, HSP90AB1 represent ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-08-17 | PXD018301 | Pride
Exosomes  extracellular vesicles  proteomics  cancer  liquid biopsy  biomarkers  mass spectrometry  early cancer detection 
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