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TranscriptomicsGene expression profiling of individual human oocytes and embryos
Early development in humans is characterised by low and variable embryonic viability, reflected in low fecundity and high rates of miscarriage, relative to other mammals. Data from assisted reproduction programmes provides additional evidence that this is largely mediated at the level of embryonic ...
ORGANISM(S): Homo sapiens 
2013-12-13 | E-MEXP-3870 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Xenopus tropicalis tadpole tail tissue regeneration following removal
In this experiment, we show transcription profiling of the Xenopus tropicalis tadpole tail tissue regeneration following removal. The tail tissues include its spinal cord, notochord, muscle, and dorsal aorta. We characterized the early, intermediate, and late stages of Xenopus tropicalis tail regene...
ORGANISM(S): Xenopus tropicalis 
2010-10-01 | E-MEXP-2420 | biostudies-arrayexpress
UnknownComparative efficacy and safety of etanercept and adalimumab in the treatment of polyarticular juvenile idiopathic arthritis.

Objective

This study aims to evaluate the efficacy and safety of Etanercept and Adalimumab in the treatment of polyarticular juvenile idiopathic arthritis (pJIA).

Methods

From Jan 2021 to Oct 2023, 66 pJIA patients were prospectively randomized into Etanercept (n = 33) and Adalimumab ...
S-EPMC11948626 | biostudies-literature
UnknownMetabolic profiling and gene expression analyses shed light on the cold adaptation mechanisms of Saposhnikovia divaricata (Turcz.) Schischk.
The northeastern region of China experiences a distinctly cold climate influenced by the Siberian High during the winter months, thus resulting in severe cold weather conditions. Snow cover is prevalent and can persist for several months. This prolonged exposure to low temperatures necessitates spec...
S-EPMC11868412 | biostudies-literature
ProteomicsProteomic analysis of Acinetobacter baylyi ADP1 under exposure of disinfectants
The goals of this study are to use SWATH-MS to detect bacterial proteomic profiles of wild-type Acinetobacter baylyi ADP1, and its protein response under the exposure of disinfectants, including chloramine and free chlorine. The concentrations of disinfectants were 10 mg/L. The group without dosing ...
ORGANISM(S): Acinetobacter sp. 
2021-09-09 | PXD016794 | Pride
Bacteria Disinfectants Swath-ms Acinetobacter baylyi adp1 
ProteomicsProteomic analysis of Acinetobacter baylyi ADP1 under exposure of non-antibiotic pharmaceuticals
The goals of this study are to use SWATH-MS to detect bacterial proteomic profiles of wild-type Acinetobacter baylyi ADP1, and its protein response under the exposure of non-antibiotic pharmaceuticals, including ibuprofen, naproxen, gemfibrozil, diclofenac, propanolol, and iopromide. The concentrati...
ORGANISM(S): Acinetobacter sp. 
2020-05-22 | PXD016798 | Pride
Bacteria Non-antibiotic pharmaceuticals Swath-ms Acinetobacter baylyi adp1 
ProteomicsProteomic analysis of E. coli K-12 LE392, P. putida KT2440 under exposure of six non-antibiotic pharmaceuticals
The goals of this study are to use SWATH-MS to detect bacterial proteomic profiles of E. coli K-12 LE392 with conjugative RP4 plasmid, P. putida KT2440, and their protein response under the exposure of six kinds of non-antibiotic pharmaceuticals, i.e., ibuprofen (ibu), naproxen (nap), gemfibrozil (g...
ORGANISM(S): Escherichia coli Pseudomonas putida KT2440 
2022-02-15 | PXD012642 | Pride
Non-antibiotic pharmaceuticals Swath-ms P. putida E. coli 
UnknownNotch-1 suppressed vascular dementia via modulating AMPK/mTOR/TFEB/YAP signaling induced ferroptosis.

Objective

The aim of this study is to clarify the molecular mechanism by which Notch-1 prevents vascular dementia (VD) by preventing ferroptosis caused by the AMPK/mTOR/TFEB/YAP pathway.

Methods

Thirty male SD rats were used in the in vivo tests. They were split into three groups at r...
S-EPMC12903360 | biostudies-literature
UnknownCACNA1C rs1006737 SNP increases the risk of essential hypertension in both Chinese Han and ethnic Russian people of Northeast Asia.

Abstract

Voltage-gated Ca2+ channels play a key role in the regulation of arterial tone and blood pressure. The aim of this study was to determine whether the association of calcium voltage-gated channel subunit alpha1 C (CACNA1C) rs1006737 with essential hypertension (EH) exists in both Chi...
S-EPMC7909128 | biostudies-literature
UnknownClearance of Somatic Mutations at Remission and the Risk of Relapse in Acute Myeloid Leukemia.
Purpose The aim of the current study was to determine whether the degree of mutation clearance at remission predicts the risk of relapse in patients with acute myeloid leukemia (AML). Patients and Methods One hundred thirty-one previously untreated patients with AML who received intensive induction ...
S-EPMC6008108 | biostudies-literature
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