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In this study, we investigated the impact of metformin on the cellular ubiquitinome and associated protein turnover. Through an integrated analysis combining ubiquitinome profiling with pulsed metabolic labeling, we found that metformin markedly suppresses global protein ubiquitination, including va...
ORGANISM(S): Homo Sapiens 
2025-09-26 | PXD065302 |
This study explores the crucial role of the nucleolus-specific RNA helicase DDX18 in maintaining the pluripotency of human embryonic stem cells. We demonstrate that DDX18 coordinates nucleolus phase separation and chromatin organization by interacting with NPM1 in the granular component of the nucle...
ORGANISM(S): Homo sapiens (Human) 
2024-11-18 | PXD057813 | Pride
Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal maintenance and application of embryonic stem cells (ESCs). While the protein-protein interactions of core pluripotency factors have been identified in mouse ESCs, their interactome in human ESCs (hESCs) has not ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-12 | PXD026556 | Pride
Affinity capture of PRC2 complex and its reader protein BP1
ORGANISM(S): Fusarium Graminearum Ph-1 
2021-08-26 | PXD028134 |
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