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TranscriptomicsTranscription profiling of human normal subjects and IPAH patients to examine the effect of BMP-2 on pulmonary artery smooth muscle cells
Bone morphogenetic proteins (BMP) inhibit proliferation and induce apoptosis in pulmonary artery smooth muscle cells (PASMC) from normal subjects. Dysfunction of BMP signaling due to mutations in and/or downregulation of BMP receptors has been implicated in idiopathic pulmonary arterial hypertension...
ORGANISM(S): Homo sapiens 
2007-09-07 | E-GEOD-2559 | biostudies-arrayexpress
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ProteomicsSARS-CoV-2 ORF8 interactome in the secretory pathway
The replication machinery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely associated with the endoplasmic reticulum (ER) in host cells. Activation of the unfolded protein response (UPR) is a strategy hijacked by coronavirus to facilitate its replication and suppress ho...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032035 | Pride
Orf8 2-d gel Endoplasmic reticulum Lc-ms/ms 
UnknownUSP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.
Not available
S-EPMC10282087 | biostudies-literature
UnknownEngineering Polyzwitterion and Polydopamine Decorated Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a pH-Sensitive Drug Delivery.
Not available
S-EPMC6415439 | biostudies-literature
MetabolomicsMulti-kingdom gut microbiota dysbiosis is associated with the development of pulmonary arterial hypertension

Gut microbiota dysbiosis has been implicated in pulmonary arterial hypertension (PAH). However, most studies have focused on the bacterial community and the exact role and mechanisms of multi-kingdom gut microbiota, including bacteria, archaea and fungi in PAH remains largely unclear. Idiopathic ...

2025-05-12 | MTBLS10563 | MetaboLights
ProteomicsIdentification of Small Open Reading Frame-encoded Peptides in Glioma by an Optimized Proteomics Strategy
Small open reading frame-encoded peptides (SEPs) are peptides or proteins encoded by previously unannotated sequences in the genome. Although ribosome profiling and bioinformatics could predict a large number of SEPs, mass spectrometry (MS) is the only direct method for their identification. However...
ORGANISM(S): Homo Sapiens 
2025-05-05 | PXD058073 |
ProteomicsPlasma proteome profiling combined with clinical and genetic features reveals pathophysiological characteristics of β-thalassemia
The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducte...
ORGANISM(S): Homo Sapiens 
2022-03-10 | PXD032179 |
ProteomicsHDL Quality Features Revealed by Proteome-Lipidome Connectivity are Associated with Atherosclerotic Disease
The “quality” rather than “quantity” of lipoprotein particles is more relevant to cardiovascular diseases (CVD), since lipoprotein particles are highly heterogeneous. However, the targeted separation, detection, and exploration of the heterogeneous on omic-scale for lipoprotein remain challenging an...
ORGANISM(S): Homo Sapiens 
2020-02-15 | PXD017529 |
ProteomicsHDL quality feature revealed by proteome-lipidome connectivity are associated with atherosclerotic disease
Lipoprotein, especially high density lipoprotein (HDL) particles are composed of multiple heterogeneous subgroups containing various proteins and lipids. The molecular distribution among these subgroups is closely related to cardiovascular disease (CVD). Here, we established high-resolution proteomi...
ORGANISM(S): Oryctolagus Cuniculus Homo Sapiens 
2021-09-03 | PXD028209 |
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