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ProteomicsAcetylated proteomic identification of stored platelets
In this project, the protein acetylation levels in human platelets and in WT and SIRT3-/- mouse platelets during storage were examined.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-06-09 | PXD026341 | Pride
Stored platelets  acetylation  sirt3 
UnknownBottom-up precise synthesis of stable platinum dimers on graphene.
Not available
S-EPMC5715161 | biostudies-literature
TranscriptomicsRegulation of pluripotency and self-renewal of ES cells through epigenetic-threshold modulation and mRNA pruning
The core pluripotency factors (Oct4, Sox2, and Nanog), the Myc network, and the chromatin-modifying complexes such as PRC2 ensure the pluripotency and self-renewal of ES cells (ESC). How these factors coordinate with one another remains poorly understood. We report that Utf1, a target of Oct4 and So...
ORGANISM(S): Mus musculus 
2012-10-26 | E-GEOD-39513 | biostudies-arrayexpress
UnknownConjugated dual size effect of core-shell particles synergizes bimetallic catalysis.
Not available
S-EPMC9892500 | biostudies-literature
ProteomicsLysargiNase Enhances the Protein Identification on FFPE Samples
Formalin-Fixed Paraffin-Embedded (FFPE) samples are treasure for proteomic studies of disease. However, their usage is hampered for proteomics study because of the crosslink among proteins, and protein vs nucleic acid. Even worse, other covalent chemical modifications like methylation introduced by ...
ORGANISM(S): Mus Musculus 
2019-02-15 | PXD012738 |
MetabolomicsAberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

OBJECTIVE: Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise relationships between the intestinal microbiome composition, uraemic toxins and rena...

2020-10-20 | MTBLS700 | MetaboLights
ProteomicsProteome, lysine acetylome and succinylome identify post-translational modification of STAT1 as a novel drug target in silicosis
Inhalation of crystalline silica dust induces incurable lung damage, silicosis and pulmonary fibrosis. However, the mechanisms of the lung injury remain poorly understood, with limited therapeutic options aside from lung transplantation. Post-translational modifications can regulate the function of...
ORGANISM(S): Mus Musculus 
2024-02-04 | PXD049146 |
ProteomicsProteome and phosphoproteome landscape of silicosis occurrence in mice model
To map the multi-omics atlas of silicosis progression, we collected four replicates of whole lung lobes from mice at different stages (W2, W4, W6, W10) after silica-treated as well as W6 after PBS-treated (as control). Then we performed (phospho) proteome analysis as well as bioinformatic analysis.
ORGANISM(S): Mus Musculus 
2021-08-04 | PXD027693 |
ProteomicsTransketolase promotes MAFLD by limiting inosine-induced mitochondrial activity (Proteomics)
Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse M...
ORGANISM(S): Homo Sapiens 
2024-02-26 | PXD050130 |
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