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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
TranscriptomicsMutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability
K-ras mutations are observed in around 40% human colorectal adenomas and carcinomas and contribute to the pathogenesis of human and rodent colorectal tumour formation. Previously, we developed and characterised a strain of transgenic mice with inducible intestinal epithelial expression of K-rasVal12...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-24010 | biostudies-arrayexpress
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
ProteomicsIdentification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis
Background: Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia caused by accumulation of pulmonary fluid, which is related to inflammatory cell infiltration, impaired tight junction of pulmonary epithelium and impaired Na, K-ATPase function, especially Na, K-ATPase α...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032209 | Pride
Lipopolysaccharide A549 cell. Proteomics Na K-atpase α1 Ards 
ProteomicsDDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition
In efforts to identify additional therapeutic targets for Acute Myeloid Leukemia (AML), we performed a high-throughput screen that includes 56 primary specimens tested with 10,000 structurally diverse small molecules. One specific hit, called S656 acts as a molecular glue degrader (MGD), that mediat...
ORGANISM(S): Homo sapiens (Human) 
2025-03-18 | PXD061850 | Pride
Molecular glue degrader Cdk12 Ddb1 Cyclin k Acute myeloid leukemia 
ProteomicsIdentification of PP1c-PPP1R12A Substrates Using K-BIPS (Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates)
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) interacts with the catalytic subunit of protein phosphatase 1 (PP1c) to form one of the many protein phosphatase 1 complexes, PP1c-PPP1R12A (or myosin phosphatase). In addition to a well-documented role in muscle contraction, the PP1c-PPP1R12A ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-24 | PXD035212 | Pride
Protein phosphatase 1  pp1  ppp1r12a  chemoproteomics  substrate identification 
ProteomicsIdentification of PP1c-PPP1R12A Substrates Using K-BIPS (Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates)
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) interacts with the catalytic subunit of protein phosphatase 1 (PP1c) to form one of the many protein phosphatase 1 complexes, PP1c-PPP1R12A (or myosin phosphatase). In addition to a well-documented role in muscle contraction, the PP1c-PPP1R12A ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-24 | PXD035213 | Pride
Protein phosphatase 1  pp1  ppp1r12a  chemoproteomics  substrate identification 
ProteomicsIdentification of PP1c-PPP1R12A Substrates Using K-BIPS (Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates)
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A) interacts with the catalytic subunit of protein phosphatase 1 (PP1c) to form one of the many protein phosphatase 1 complexes, PP1c-PPP1R12A (or myosin phosphatase). In addition to a well-documented role in muscle contraction, the PP1c-PPP1R12A ...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-24 | PXD035211 | Pride
Protein phosphatase 1  pp1  ppp1r12a  chemoproteomics  substrate identification 
TranscriptomicsRNAseq of murine fetal liver cells overexpressing hnRNP K
Background: hnRNP K is an RNA-binding protein that's been implicated in oncogenesis, particularly in hematological disorders. Intent: To determine the impact of hnRNP K overexpression on RNA expression in murine fetal liver cells. Experimental Workflow: Fetal liver cells were subjected to retrovial ...
ORGANISM(S): Mus musculus 
2023-06-10 | E-MTAB-11886 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli K-12 mutant ycfR biofilm vs wild type 15 hr LB glu biofilm cells
E. coli K-12 BW25113 mutant strain ycfR expression in biofilm cells relative to E. coli wild-type strain expression in biofilm cells. All samples cultured in LB glu with glass wool Experiment Overall Design: Strains: E. coli K-12 BW25113 wild type and mutant ycfR Experiment Overall Design: Medium: ...
ORGANISM(S): Escherichia coli 
2008-06-14 | E-GEOD-5904 | biostudies-arrayexpress
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