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ProteomicsThe Cancer Cell Target Discovery. Comparing Laboratory Evolution of Expanded DNA Six-Nucleotide Alphabets with Standard Four-Nucleotide Alphabets
Artificial evolvable genetic information systems (AEGIS) are DNA-like molecules that can be copied, support laboratory in vitro evolution (LIVE), and evolve to give AegisBodies, analogs of antibodies. However, unlike DNA aptamers built from four different nucleotides, AegisBodies are built from si...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055130 | Pride
Target determination Aptamer Molecular interactions Cancer cell Unnatural bases 
ProteomicsThe Cancer Cell Target Discovery. Comparing Laboratory Evolution of Expanded DNA Six-Nucleotide Alphabets with Standard Four-Nucleotide Alphabets
Artificial evolvable genetic information systems (AEGIS) are DNA-like molecules that can be copied, support laboratory in vitro evolution (LIVE), and evolve to give AegisBodies, analogs of antibodies. However, unlike DNA aptamers built from four different nucleotides, AegisBodies are built from si...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055115 | Pride
Target determination Aptamer Molecular interactions Cancer cell Unnatural bases 
ProteomicsThe Cancer Cell Target Discovery. Comparing Laboratory Evolution of Expanded DNA Six-Nucleotide Alphabets with Standard Four-Nucleotide Alphabets
Artificial evolvable genetic information systems (AEGIS) are DNA-like molecules that can be copied, support laboratory in vitro evolution (LIVE), and evolve to give AegisBodies, analogs of antibodies. However, unlike DNA aptamers built from four different nucleotides, AegisBodies are built from si...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055107 | Pride
Target determination Aptamer Molecular interactions Cancer cell Unnatural bases 
TranscriptomicsTranscription profiling of mouse 344SQ lung adenocarcinoma cells under forced miR-200 expression
Metastatic disease is a primary cause of cancer-related death, and factors governing tumor cell metastasis have not been fully elucidated. Here we addressed this question by using tumor cell lines derived from mice that develop metastatic lung adenocarcinoma owing to expression of mutant K-ras and p...
ORGANISM(S): Mus musculus 
2009-11-28 | E-GEOD-15741 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse 344SQ lung adenocarcinoma cells with high metastatic potential (syngeneic mouse model)
The biologic basis for NSCLC metastasis is not well understood. Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. As a tool to investigate...
ORGANISM(S): Mus musculus 
2009-11-28 | E-GEOD-14458 | biostudies-arrayexpress
ProteomicsUncovering protein regulation during adventitious root formation in Platycladus orientalis cuttings
Cell totipotency and pluripotency are the cellular basis for root regeneration in Platycladus orientalis cuttings, and the regeneration of adventitious roots is a key determinant for improving stem-cutting. However, the cellular basis and physiological regulation of adventitious root formation are s...
ORGANISM(S): Platycladus Orientalis 
2024-05-24 | PXD052541 |
ProteomicsIdentification of p72-interacting proteins in porcine alveolar macrophages
To explore the potential mechanisms regulating p72 stability, we performed co-immunoprecipitation using an anti-p72 antibody in ASFV-infected PAMs, followed by mass spectrometry analysis to identify host factors interacting with p72.
ORGANISM(S): Sus Scrofa Domesticus 
2026-01-18 | PXD073232 |
Proteomicsproteomic analysis in cataract of Ailuropoda melanoleuca (Giant panda)
proteomic analysis between cataract of Ailuropoda melanoleuca (Giant panda) and normal panda
ORGANISM(S): Ailuropoda Melanoleuca 
2022-01-18 | PXD031039 |
TranscriptomicsCancers originate preferentially in adult tissue stem cells
Stem cells have long been regarded as a potential origin of cancer. But cancers could also arise from mutated, differentiated cells that reacquire stem cell properties. Here, in mice harboring conditional oncogenic and lineage tracing alleles, we show that cancers develop from Prom1+ (CD133) cells...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-40634 | biostudies-arrayexpress
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