Sort   by:  
 Page size 
ProteomicsImmunoprecipitation of PTEN coupled Nano-LC−ESI-MS/MS
Nuclear localization of PTEN is essential for its tumor suppressive role, and loss of nuclear PTEN is more prominent than cytoplasmic PTEN in many kinds of cancers. However, nuclear PTEN-specific regulatory mechanisms were rarely reported. Based on the finding that nuclear PTEN is more unstable than...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD017983 | Pride
Immunoprecipitation Pten Nano-lc−esi-ms/ms 293t 
ProteomicsPTENa/b paradoxically promote carcinogenesis through WDR5-H3K4me3 axis
PTEN, a widely investigated tumor suppressor, has at least two longer translational variants, PTEN and . However, the regulation and precise roles of endogenous PTEN/ in tumorigenesis remain greatly unknown. Here we show that USP9X and FBXW11 selectively regulate the stability of PTEN/ but not PTEN ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-14 | PXD013196 | Pride
Ptena  ptenb  pten  usp9x  fbxw11  ubiquitination wdr5  carcinogenesis 
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
Sort   by:  
 Page size