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UnknownGASZ directly recruits MILI to the intermitochondrial cement for piRNA biogenesis and male germ cell development.
Not available
S-EPMC12507516 | biostudies-literature
TranscriptomicsExpression of SUDHL-1 cell line treated by ALK inhibitors
In this study we compared the effects of ALK inhibitor on the gene expression, activation of cell signaling pathways, and functional properties of cells derived from a patient with Anaplastic Large Cell Lymphoma. we used microarrays to map the genome-wide gene expression patterns in ALK+TCL cells in...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-50803 | biostudies-arrayexpress
UnknownMicroglia-derived nanovesicles synchronize macroautophagy and chaperone-mediated autophagy for Alzheimer's disease therapy.
Not available
S-EPMC12583606 | biostudies-literature
TranscriptomicsRNA-seq of human neuroblastoma cell lines where RET is knocked out
ALK is driving neuroblastoma (NB) and RET has been shown to be a downstream target of ALK signaling in NB. To get a better understanding of the role of RET in NB, the gene was knocked out in SKNAS cell lines.
ORGANISM(S): Homo sapiens 
2021-04-14 | E-MTAB-10032 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment (dataset 1)
Medical research focuses on disease-specific genes. By contrast, here we systematically examined the roles of shared genes for disease susceptibility and as therapeutic and diagnostic targets. Meta-analysis of all published disease-related genome-wide association studies (GWAS) showed that T helper ...
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44956 | biostudies-arrayexpress
GenomicsPan-neuroblastoma analysis reveals age- and ROS-associated drivers and novel therapeutic targets
Neuroblastoma is a pediatric malignancy with heterogeneous clinical outcomes depending on age and other factors. To better understand neuroblastoma pathogenesis, here we analyze whole-genome, whole-exome and/or transcriptome sequencing data from 702 neuroblastoma samples, half of which are new data....
EGAS00001003931 | EGA
TranscriptomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases (exon array)
In this work we present an analytical strategy to systematically identify early regulators by combining gene regulatory networks (GRN) with GWAS. We hypothesized that early regulators in T-cell associated diseases could be found by defining upstream transcription factors (TFs) in T-cell differentia...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-60677 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Altered Expression of miRNAs and piRNAs in the Testes of Mtdh exon 3-deficient Mice
Purpose: To identify the correlation of the expression of testicular miRNAs and piRNAs with the infertility of Mtdh exon 3 deficient mice Methods: Total RNAs from individual testis of two WT mice and three homozygous Mtdh exon 3-depleted mice were used to prepare the miRNA sequencing library. After ...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-62330 | biostudies-arrayexpress
UnknownEGF receptor-mediated FUS phosphorylation promotes its nuclear translocation and fibrotic signaling.
Not available
S-EPMC7480104 | biostudies-literature
TranscriptomicsIntegrated genomic and prospective clinical studies show the importance of modular pleiotropy for disease susceptibility, diagnosis and treatment
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-03-07 | E-GEOD-44966 | biostudies-arrayexpress
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