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ProteomicsMoCox6 is a regulator of mitophagy and a druggable target in Magnaporthe oryzae
A convergent screening strategy was employed to systematically identify mitophagy regulators within the IMM. The quantitative proteomic comparison between the WT and ΔMoatg1 mutant under nutrient-replete (CM) and nitrogen-starvation (CM-N) conditions was conducted using TMT-labeled quantitative prot...
ORGANISM(S): Pyricularia oryzae 70-15 
2026-09-14 | PXD075441 | Pride
Mitophagy Succinylation Cox6 Fungicide Magnaporthe oryzae 
ProteomicsIntegrative Proteogenomic Characterization Reveals Therapeutic Targets in Poorly Differentiated and Anaplastic Thyroid Cancers
In our study, we constructed a multicenter thyroid-cancer cohort consisting of 467 formalin-fixed paraffin-embedded (FFPE) samples, among which WES, proteome, and phosphorylated proteome analysis were conducted. Thyroid tumors consisted of 124 ATC samples, 47 PDTC samples and 177 PTC samples (includ...
ORGANISM(S): Homo Sapiens 
2025-03-16 | PXD054521 |
MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
ProteomicsYi-xin-shu Capsule Ameliorates Cardiac Hypertrophy by Regulating RB/HDAC1/GATA4 Signaling Pathway in Abdominal Aorta Coarctation-Induced Rat Model
Background: Cardiac hypertrophy (CH) is the main pathological basis of malignant cadiovascular diseases such as chronic heart failure (CHF). Mitigating and preventing CH is the key strategy for the treatment of ventricular remodeling in CHF. Yi-Xin-Shu capsule (YXS) is highly applied in clinical tre...
ORGANISM(S): Rattus Rattus 
2021-05-26 | PXD026267 |
ProteomicsAdhesins, which could adhere to the duck embryo cell that belongs to the outer membrane proteins of Riemerella anatipestifer RA-YM strain sequencing by mass spectrometry (LC-MS/MS)
Infectious serositis of ducks caused by Riemerella anatipestifer infection has brought great losses to poultry industry all over the world. Adhesion and invasion were important pathway of the infection of Riemerella anatipestifer. Gram-negative pathogens’ adhesion and invasion of host cells by means...
ORGANISM(S): Riemerella Anatipestifer Ra-ym 
2024-10-27 | PXD057236 |
ProteomicsDIA proteomics analysis of mice in models of myocardial infarction and heart failure with preserved ejection fraction (HFpEF).
The dataset includes two parts: a) Proteomics of mouse heart tissue 14 days after myocardial infarction and long-term exercised mice post-myocardial infarction for 14 days; b) Cardiac proteomics of a model of heart failure with preserved ejection fraction (HFpEF) induced by L-NAME and high-fat diet-...
ORGANISM(S): Mus Musculus 
2024-04-05 | PXD051242 |
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