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MetabolomicsPu-erh tea and theabrownin ameliorate metabolic syndrome in mice via potential microbiota-gut-liver-brain interactions
Metabolic syndrome (MS) is a common metabolic disorder characterized by obesity, insulin resistance, cardiovascular disease and gut microbiota dysbiosis. Pu-erh tea and its ingredient theabrownin have known functions on the reduction of body weight gain and fat accumulation. However, few studies sys...
2024-09-25 | MTBLS2594 | MetaboLights
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
ProteomicsAnalysis of muscular proteomics of deep pressure ulcers reveals JAK2 influence on muscle autophagy and apoptosis
Pressure ulcers (PU) is a complex and serious clinical problem. Deep tissue injury is either the outcome or the trigger of deep PU. However, the cellular and molecular mechanisms that contribute to the pathogenesis of deep PU remain unclear. In this study, the degeneration characteristics, increased...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD009512 | Pride
Proteomics Ischemia/reperfusion injury Deep pressure ulcers Jak2 Autophagy & apoptosis 
Proteomicsrat cecal microbiota LC-MSMS
Pu-erh tea has attracted increasing attention worldwide because of its special flavor and health effects, but its impact on composition and function of the gut microbiota remains unclear. The aim of this study was to investigate effects of aqueous extracts of fermented (ripe) and non-fermented (raw)...
ORGANISM(S): Microbiota 
2022-03-03 | PXD010972 | Pride
Lc-msms Cecal microbiota Pu-erh tea Wista rats 
ProteomicsPromotion of Subtotal Uterine Reconstruction by a Tissue-engineered Uterus Biomimeticing Structure and Extracellular Matrix Microenvironment
To better characterize the ECM signature of the ECMEC-SIS and ECMSMC-PU/SIS, a 4D label free proteomic analyses was carried out. In total 2761 and 1520 proteins have been identified for the ECMEC-SIS and ECMSMC-PU/SIS, respectively, including 1055 in common . An ECM-specific categorization database...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041467 | Pride
Cell-derived ecm Smooth muscle Endometrial epithelium 
UnknownThe Clinical Significance of RMI2 in Hepatocellular Carcinoma.
Not available
S-EPMC8516379 | biostudies-literature
UnknownPU.1-c-Jun interaction is crucial for PU.1 function in myeloid development.
Not available
S-EPMC9474506 | biostudies-literature
UnknownIntegrated Meta-omics Approaches To Understand the Microbiome of Spontaneous Fermentation of Traditional Chinese Pu-erh Tea.
Not available
S-EPMC6867877 | biostudies-literature
TranscriptomicsPU.1 restricts adult hematopoietic stem cell proliferation via cell specific autoregulation
To guarantee blood supply throughout adult life hematopoietic stem cells (HSCs) need to carefully balance between self-renewing cell divisions and quiescence. Identification of genes controlling HSC self-renewal is of utmost importance given that HSCs are the only stem cells with broad clinical appl...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-33031 | biostudies-arrayexpress
UnknownPU.1-CD23 signaling mediates pulmonary innate immunity against Aspergillus fumigatus infection by driving inflammatory response.
Not available
S-EPMC9844028 | biostudies-literature
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