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ProteomicsGlobal lysine crotonylation and 2-hydroxyisobutyrylation in phenotypically different Toxoplasma gondii parasites
Toxoplasma gondii is a unicellular protozoan parasite of the phylum Apicomplexa. The parasite repeatedly goes through a cycle of invasion, division and induction of host cell rupture, which is an obligatory process for proliferation inside warm-blooded animals. It is known that the biology of the pa...
ORGANISM(S): Toxoplasma gondii 
2019-09-09 | PXD014133 | Pride
Metabolism Protein posttranslational modification Toxoplasma gondii Function Crotonylation 2-hydroxyisobutyrylation 
UnknownRGF Gene Family Analysis and Functional Evidence for RGF8-Mediated Salt Stress Tolerance in Brassica Species.
Not available
S-EPMC11939866 | biostudies-literature
ProteomicsAcetylation Coordinates the Crosstalk between Carbon Metabolism and Ammonium Assimilation
Enteric bacteria use up to 15% of their cellular energy for ammonium assimilation via glutamine synthetase (GS)/glutamate synthase (GOGAT) and glutamate dehydrogenase (GDH), in response to low or high ammonium availability. However, the sensory mechanisms for effective and appropriate coordination b...
ORGANISM(S): Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
2023-06-21 | PXD039658 | Pride
Ammonium assimilation Acetylation Coordination Carbon metabolism 
ProteomicsLandscapes of post-translational modifications in Trypanosoma parasites
Proteins of all living cells undergo a myriad of posttranslational modifications (PTMs) that are critical to multifarious life processes. In this study, we describe the first comprehensive multiple PTM-omics atlas in parallel with quantitative proteome analyses of two representative species of trypa...
ORGANISM(S): Trypanosoma brucei brucei 
2020-06-30 | PXD016425 | Pride
Trypanosoma brucei  trypanosoma evansi  post-translational modification  acetylation  crotonyltion  2-hydroxyisobutyrylation  malonylation  succinylation  ubiquitination  trimethylation  phosphorylation  n-glycosylation  o-glcnacylation 
ProteomicsExploring the molecular mechanism of dihydroartemisinin regulating spleen immunity based on proteomics and phosphoproteomic
The molecular mechanisms through which dihydroartemisinin (DHA) induces immunomodulation in vivo remain unclear. Herein, DHA-regulated proteins and their phosphorylation profiles were identified and characterized, in the spleens of mice, using proteomics and phosphoproteomic approaches. We found tha...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-29 | PXD030353 | Pride
Dihydroartemisinin Phosphoproteomic Proteomics Immunomodulatory activity 
ProteomicsLysine lactylation critically regulated energy metabolism of the protozoan parasite Trypanosoma brucei
Lysine lactylation, a new post-translational modification identified on histones of human and mouse cells, stimulates gene transcription from chromatin directly. However, very little is known in the scope and cellular distribution of lactylated proteins. In the present study, we conducted the first ...
ORGANISM(S): Trypanosoma brucei 
2021-10-01 | PXD023011 | Pride
Lysine lactylation  trypanosoma brucei  energy metabolism  glycolysis 
ProteomicsGlucosidase Alpha Neutral C Promotes Influenza Virus Replication by Inhibiting Proteosome-Dependent Degradation of Hemagglutinin
The H7N9 influenza virus poses a significant threat to human health, and the mechanism by which it infects humans remains incompletely understood. Our investigation has unveiled significant insights into the role of glucosidase alpha, neutral C (ganc) gene in human H7N9 infections. Through whole gen...
ORGANISM(S): Homo Sapiens 
2025-03-10 | PXD061732 |
ProteomicsComputational Optimization of Spectral Library Size Improves DIA-MS Proteome Coverage and Applications to 15 Tumors
a computational strategy for the size optimization of DIA spectral library, which refines a comprehensive library by a prior analysis of DIA data of a particular tissue type
ORGANISM(S): Homo Sapiens 
2021-12-27 | PXD030648 |
ProteomicsDPHL v2: An updated and comprehensive DIA pan-human assay library for quantifying more than 14,000 proteins
we generated DPHL v2 from 1608 DDA-MS data acquired using Orbitrap mass spectrometers. The data included 586 DDA-MS newly acquired from 17 tissue types, while 1022 files were derived from DPHL v1. DPHL v2 thus comprises data from 24 sample types, including several cancer types . We generated four va...
ORGANISM(S): Homo Sapiens 
2023-01-18 | PXD039313 |
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