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UnknownDifferentially expressed genes and therapeutic targets for nonalcoholic fatty liver disease from transcriptomic techniques.
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver conditions globally. Lifestyle interventions are currently available as the main treatment modality. However, there is an urgent need to develop new therapeutic approaches for NAFLD owing to its complex pathological mec...
S-EPMC12643743 | biostudies-literature
UnknownGlobal Identification, Classification, and Expression Analysis of MAPKKK genes: Functional Characterization of MdRaf5 Reveals Evolution and Drought-Responsive Profile in Apple.
Mitogen-activated protein kinase kinase kinases (MAPKKKs) are pivotal components of Mitogen-activated protein kinase (MAPK) cascades, which play a significant role in many biological processes. Although genome-wide analysis of MAPKKKs has been conducted in many species, extant results in apple are s...
S-EPMC5647345 | biostudies-literature
UnknownThe expression of a tubby-like protein from Malus domestica (MdTLP7) enhances abiotic stress tolerance in Arabidopsis.

Background

Tubby-like proteins (TLPs), characterized by a signature tubby domain, are widespread in plants and animals. To date, only plant TLPs involved in multifarious stress responses and male gametophyte development have been identified. However, studies on the molecular functions of pla...
S-EPMC6366083 | biostudies-literature
UnknownThe thiol-disulfide exchange activity of AtPDI1 is involved in the response to abiotic stresses.

Background

Arabidopsis protein disulfide isomerase 1 (AtPDI1) has been demonstrated to have disulfide isomerase activity and to be involved in the stress response. However, whether the anti-stress function is directly related to the activities of thiol-disulfide exchange remains to be elucid...
S-EPMC8609882 | biostudies-literature
UnknownNOD2 maybe a biomarker for the survival of kidney cancer patients.

Background

Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) may play an important role in the outcome of kidney cancer patients. To explore the relationship between NOD2 and the prognosis of kidney cancer patients, a databank-based reanalysis was conducted.

Materials ...

S-EPMC5731890 | biostudies-literature
UnknownAssociation between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly.

Background

Age-related hearing impairment (ARHI) has attracted increasing attention recently. It is caused by genetic and environmental factors. A number of ARHI-related genes have been found. This study aimed to detect the potential association between NR3C1 gene polymorphisms and ARHI by m...
S-EPMC8320226 | biostudies-literature
UnknownThe Importance of Conserved Serine for C-Terminally Encoded Peptides Function Exertion in Apple.

Background

The C-terminally encoded peptide (CEP) family has been shown to play vital roles in plant growth. Although a genome-wide analysis of this family has been performed in Arabidopsis, little is known regarding CEPs in apple (Malus domestica).

Methods

Here, a comprehensiv...
S-EPMC6387203 | biostudies-literature
UnknownKnowledge, attitudes, and practice related to tooth loss and dentures among patients with dental arch deficiencies.

Background

Tooth loss is a common problem that affects many people worldwide. Exploring knowledge, attitude, and practice (KAP) among patients can identify barriers and challenges in following recommended practices, providing valuable insights for dental healthcare providers, policymakers, a...
S-EPMC11227721 | biostudies-literature
ProteomicsA SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Purposing
An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 170,000 people since the end of 2019, killed over 7,400, and caused worldwide social and economic disruption. SARS-CoV-2 infection has a mortality rate of 3.4% among confirmed case...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 (ncbitaxon:2697049) Homo Sapiens (ncbitaxon:9606) 
2020-03-24 | MSV000085144 | MassIVE
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