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MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicscTAGE5 is essential for adipogenesis and adipose tissue development
White adipocytes serve as primary energy reservoirs and their malfunction is linked to different metabolic disorders, yet the mechanisms underlying cellular specialization, a critical step during adipogenesis remain unknown. Here, we reveal the indispensable role of cutaneous T cell lymphoma-associa...
ORGANISM(S): Mus Musculus 
2025-01-07 | PXD059525 |
ProteomicsProteomic study of Toxoplasma gondii infection in cibeaver
Proteomics in South China Agricultural University essentially refers to the study of protein characteristics at a large-scale level, including protein expression level, post-translational modification, protein-protein interaction and so on, so as to obtain an overall and comprehensive understanding ...
ORGANISM(S): Paguma Larvata 
2022-11-09 | PXD038083 |
ProteomicsThermal proteome profiling of itaconate interactome in macrophages
Thermal proteome profiling of itaconate in RAW 264.7 lysate
ORGANISM(S): Mus Musculus 
2025-02-11 | PXD060673 |
ProteomicsThe novels biomarkers for assessing clinical benefits of continuous renal replacement therapy in pediatric sepsis
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Continuous renal replacement therapy (CRRT) is regarded as an adjuvant therapy for critically ill, which removes excess fluids and clear uremic toxins, endotoxins, proteins, and inflammatory mediators...
ORGANISM(S): Homo Sapiens 
2022-03-25 | PXD032807 |
ProteomicsDifferential proteomic and phosphoproteomic analysis of Hnrnpk conditional knockout mouse testes
In this research, we have used a global analysis of TMT-based quantitative proteome coupled with phosphopeptide-enrichment strategies to reveal the mouse testes proteome and find the PTMs associated with the RNA binding protein hnRNPK using Hnrnpk conditional knockout mouse and WT mouse testes.
ORGANISM(S): Mus Musculus 
2024-09-14 | PXD056125 |
ProteomicsSpatial phosphoproteomics reveals phosphorylation features in liver cirrhosis
Liver cirrhosis (LC) is the end stage of chronic liver disease, characterized by pseudolobule formation and extensive fibrosis, with unclear regional dynamics of protein phosphorylation. This study used spatial phosphoproteomics combined with bioinformatics to analyze phosphorylation patterns in LC ...
ORGANISM(S): Homo Sapiens 
2025-11-21 | PXD071108 |
ProteomicsProteome, lysine acetylome and succinylome identify post-translational modification of STAT1 as a novel drug target in silicosis
Inhalation of crystalline silica dust induces incurable lung damage, silicosis and pulmonary fibrosis. However, the mechanisms of the lung injury remain poorly understood, with limited therapeutic options aside from lung transplantation. Post-translational modifications can regulate the function of...
ORGANISM(S): Mus Musculus 
2024-02-04 | PXD049146 |
ProteomicsProteome and phosphoproteome landscape of silicosis occurrence in mice model
To map the multi-omics atlas of silicosis progression, we collected four replicates of whole lung lobes from mice at different stages (W2, W4, W6, W10) after silica-treated as well as W6 after PBS-treated (as control). Then we performed (phospho) proteome analysis as well as bioinformatic analysis.
ORGANISM(S): Mus Musculus 
2021-08-04 | PXD027693 |
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