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MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
MetabolomicsMulti-omics insights into the effects of Citrus reticulata-derived Bacillus cereus C3X-5 on the fermentation quality of cigar tobacco leaves
This study investigates the potential of Bacillus cereus C3X-5, a strain isolated from Citri Reticulatae Pericarpium (CRP), as a bio-enhancer for improving cigar tobacco leaves (CTL) fermentation quality. By integrating physicochemical analysis, metagenomics, and untargeted metabolomics, we systemat...
2026-07-24 | MTBLS15119 | MetaboLights
TranscriptomicsX chromosome cDNA microarray screen of lymphoblasts from males with XLMR
The goal of this study is to identify genes that show altered transcript levels in lymphoblasts from male patients with XLMR as candidate genes that are responsible for XLMR. Keywords: disease state Using a custom X chromosome cDNA microarray, we studied X chromosome gene expression in lymphoblasts ...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-7470 | biostudies-arrayexpress
TranscriptomicsSex-dependent and -independent X-chromosome histone modifications in Drosophila melanogaster
Drosophila X chromosomes are subject to dosage compensation in males and are known to have a specialized chromatin structure in the male soma. We are interested in how specific chromatin structure change contributes to X chromosome hyperactivity and dosage compensation. We have conducted a global a...
ORGANISM(S): Drosophila melanogaster 
2010-01-11 | E-GEOD-15593 | biostudies-arrayexpress
TranscriptomicsMES-4, an autosome-associated HMT that participates in silencing the X chromosomes in the C. elegans germ line
Microarray-based expression profiling of dissected gonads from mes-4 mutants reveals that MES-4 is required to repress expression of a set of X-linked genes. We isolated dissected gonads from mes-4(bn85) mutant adults and compared to dissected gonads from wild type (N2 animals. RNA was linearly amp...
ORGANISM(S): Caenorhabditis elegans 
2010-07-01 | E-GEOD-5454 | biostudies-arrayexpress
TranscriptomicsEffect of probiotic Lactobacillus casei Zhang on liver gene expression of hypercholesterolemic rats
The hypocholesterolemic effect of probiotics has been observed, but the molecular mechanism of probiotic-host interaction is still obscure. In this study, DNA microarray technology was used to explore the gene expression profile of liver of hypercholesterolemic rats caused by administration of probi...
ORGANISM(S): Rattus norvegicus 
2011-12-31 | E-GEOD-23740 | biostudies-arrayexpress
ProteomicsProteomics analysis of the membrane vesicles in Pseudomonas aeruginosa under X-ray irradiation
Pseudomonas aeruginosa, X-ray irradiation, inner membrane blebbing, membrane vesicles Almost all bacteria produce membrane vesicles (MVs) that have been found to be generally composed of lipopolysaccharides (LPSs), phospholipids (PLs), outer membrane proteins, periplasmic proteins and peptidoglycan ...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2025-08-25 | PXD037062 | Pride
X-ray irradiation Membrane vesicles Proteomics analysis Pseudomonas aeruginosa 
ProteomicsDifferential Membrane Protein Profile in Sperm
We investigated the differential expression of the total membrane proteins of the two sperm types by using high-purity X- and Y-sperm from 20 Holstein bulls and applying the label-free proteomic technique.
ORGANISM(S): Bos Taurus 
PXD019435 |
ProteomicsCRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice
Loss of fragile X messenger ribonucleoprotein (FMRP) causes fragile X syndrome (FXS), an inherited neurodevelopmental disorder resulting in intellectual disability and autism-spectrum disorder. Despite the prevalence of the FXS, the molecular function of FMRP remains uncertain. Here, we showed that...
ORGANISM(S): Homo sapiens (Human) 
2026-04-20 | PXD067852 | Pride
Hek293t 
MetabolomicsMetabolomics Analysis Reveals Tissue-Specific Metabolite Compositions in Leaf Blade and Traps of Carnivorous Nepenthes Plants
Nepenthes is a genus of carnivorous plants that evolved a pitfall trap, the pitcher, to catch and digest insect prey to obtain additional nutrients. Each pitcher is part of the whole leaf, together with a leaf blade. These two completely different parts of the same organ were studied separately in a...
2020-07-10 | MTBLS1783 | MetaboLights
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