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MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
TranscriptomicsProbing the pan genome of a foodborne bacterial pathogen Listeria monocytogenes
Full title: Probing the pan genome of a foodborne bacterial pathogen Listeria monocytogenes: Implications for its niche adaptation, pathogenesis, and evolution Listeria monocytogenes is a foodborne bacterial pathogen well known for adaptability to diverse environmental and host niches, and a high f...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-04-06 | E-GEOD-20367 | biostudies-arrayexpress
ProteomicsProteome-wide cellular thermal shift assay reveals novel crosstalk between brassinosteroid and auxin signaling
We demonstrated that bikinin changed the thermal stability of some of its target proteins as well as several known or putative interacting proteins of Arabidopsis GSK3s. By combining the thermal- and the phospho-proteomes of bikinin we uncovered the auxin carrier PIN-FORMED1 (PIN1) as a novel substr...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-03-08 | PXD029936 | Pride
Brassinosteroids Chemical genetics Auxin，ms/ms spectra Arabidopsis cell suspension 
ProteomicsIsolation and Comprehensive Analysis of Cochlear Tissue-derived Small Extracellular Vesicles
Label-free quantitative proteomics analysis of CDsEVs, with the same amount of protein of cochlear tissues used as the control
ORGANISM(S): Mus Musculus 
2024-10-04 | PXD056591 |
ProteomicsThe protein binding with diabetes induced circulation associated circular RNA of db/db mouse heart detected by label free LC-MSMS
The protein binding with diabetes induced circulation associated circular RNA (DICAR) pf db/db mouse compared with wild type
ORGANISM(S): Mus Musculus 
2022-10-27 | PXD037745 |
ProteomicsDIA-based raw mass spectrometry proteomics data of oviduct in goat
DIA-based LC-MS/MS method was used to obtain follicular and luteal phase proteomics data from the oviducts of high- and low-fertility goats, and to mine the oviducts for biomarkers that regulate fertility in goats through bioinformatics analysis of differential proteins.
ORGANISM(S): Capra Hircus 
2022-11-13 | PXD038122 |
ProteomicsTumor-derived CDC37 inhibits antigen cross-presentation in dendritic cells and impairs anti-tumor immunity in breast cancer
Tumor mutational burden (TMB), usually representing high immunogenicity, could not always predict treatment response of immune checkpoint blockade (ICB). Here, we showed that defective antigen cross-presentation in type 1 conventional dendritic cells (cDC1) was responsible for lacking tumor-specific...
ORGANISM(S): Homo Sapiens 
2025-10-17 | PXD069576 |
ProteomicsLoss of Necdin causes social deficit and aberrant synaptic function through destabilization of SynGAP
The Ras GTPase-activating protein SynGAP interacts with PSD95 to regulate synaptic morphology and function at the postsynaptic density in neurons. Haploinsufficiency of SYNGAP1 has been linked to autism spectrum disorders (ASD) and intellectual disability (ID). While transcriptional and translationa...
ORGANISM(S): Mus Musculus 
2025-05-17 | PXD064040 |
ProteomicsThe Dynll1-Cox4il Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species
Cellular membrane proteins are a critical part of the host defense mechanisms against infection and intracellular survival of Listeria monocytogenes. The complex spatiotemporal regulation of bacterial infection by various membrane proteins has been challenging to study. Here, using mass spectrometry...
ORGANISM(S): Mus Musculus 
2020-02-17 | PXD016452 |
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