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ProteomicsDual-omics reveals the different roles of α1 and β-adrenergic receptors in acute sympathetic stress-induced cardiac inflammation
Sympathetic overactivation under strong acute stresses triggers acute cardiovascular events including myocardial infarction (MI), sudden cardiac death, and stress cardiomyopathy. α1-ARs and β-ARs, two dominant subtypes of adrenergic receptors in the heart, play a significant role in the physiologica...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-19 | PXD036011 | Pride
Adrenergic receptor Cardiac inflammation Acute sympathetic stress Dual-omics 
TranscriptomicsGenome-wide analysis of gene expression changes in mouse tongue squamous cell carcinomas induced by 4-nitroquinoline 1-oxide (4-NQO)
We hypothesized that the expression of many genes are dysregulated during oral cancer carcinogenesis. We examined genome-wide transcript levels in normal mouse tongues and the tongue squamous cell carcinomas induced by 4-NQO. The results will provide important information for the diagnosis, prevent...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-54246 | biostudies-arrayexpress
ProteomicsLysosomal-associated protein transmembrane 5, tubular senescence, and progression of CKD
After LAPTM5 was overexpressed in rat renal tubular epithelial cells (NRK52E), proteomic sequencing was performed to analyze aging and fibrosis protein changes.
ORGANISM(S): Rattus Rattus 
2024-06-05 | PXD052845 |
MetabolomicsThe Kalanchoe genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism
Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthesis that has evolved independently many times in diverse lineages of flowering plants. We hypothesize that convergent evolution of protein sequence and temporal gene expression underpins the independent emergences o...
2018-01-09 | MTBLS519 | MetaboLights
MetabolomicsCardiac untargeted lipidomics in cardiomyocyte-specific Srebp1a-Tg mice

Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired contractility and high mortality. Dysregulation of intracellular ion cycling underlies the decline in cardiac contractility. Modulation of cardiac Na+/H+ and Ca2+ handling is consider...

2026-02-20 | MTBLS13690 | MetaboLights
ProteomicsFunctional analysis of Salix purpurea genes support roles for ARR17 and GATA15 as master regulators of sex determination
The Salicaceae family is of growing interest in the study of dioecy in plants because the sex determination region (SDR) has been shown to be highly dynamic, with differing locations and heterogametic systems across taxa. Previous studies investigating the mechanisms regulating sex in the genus Sali...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2023-02-01 | MSV000091180 | MassIVE
ProteomicsQuantitative proteomic analysis of UUO-14d kidneys from Adamts18+/+ versus Adamts18−/− mice using label-free LC-MS/MS
This project aims to investigate the proteomic differences between Adamts18+/+ and Adamts18−/− mice in response to unilateral ureteral obstruction (UUO) for 14 days. Kidney tissues were collected from both genotypes and subjected to quantitative proteomic analysis using label-free LC-MS/MS-based tec...
ORGANISM(S): Mus Musculus 
2025-05-19 | PXD064042 |
ProteomicsA Tissue-Specific Atlas of Mouse N-Glycoproteome
In this study, we employed StrucGP to generate the first high-resolution and site-specific N- glycoproteomic atlas across 24 diverse mouse tissues. This comprehensive dataset provides an unprecedented insight into the tissue-specific landscape of N-glycosylation, revealing how distinct glycan struct...
ORGANISM(S): Mus Musculus 
2025-05-07 | PXD063701 |
ProteomicsSite-specific N-glycoproteomics of aging mouse uterus tissues for benchmarking the StrucGAP analysis platform
This project presents the site-specific N-glycoproteomics dataset of aging mouse uterus tissues used to demonstrate and validate StrucGAP, a modular and scalable downstream analysis platform for glycoproteomics. Uterine samples were collected from 2- and 12-month-old C57BL/6 female mice (n = 15 per ...
ORGANISM(S): Mus Musculus 
2025-04-23 | PXD063260 |
ProteomicsMS data of phosphorylation sites of IRF4/TCF3/TCF4 by p38α
To identify putative phosphorylation sites on TCF3 (E47), TCF4, and IRF4, in vitro kinase assays were performed using recombinant MKK6E (a p38α activator) and p38α as kinases, and TCF3(E47), TCF4, or IRF4 proteins as substrates, the phosphorylation sites were analyzed by mass spectrometry (MS).
ORGANISM(S): Mus Musculus 
2022-10-26 | PXD037718 |
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