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TranscriptomicsTranscription profiling of human embryonic stem cells and neuroepithelial cells
Comparing gene expressing profile of human embryonic stem cells and neuroepithelial cells differentiated from human embryonic stem cells.
ORGANISM(S): Homo sapiens 
2009-11-08 | E-MEXP-2426 | biostudies-arrayexpress
TranscriptomicsGene expression of human isogenic trisomy 21 induced pluripotent stem cells and derived neurons
Down syndrome (trisomy 21) is the most common genetic cause of intellectual disability, but the precise molecular mechanisms underlying impaired cognition remain unclear. Elucidation of these mechanisms has been hindered by the lack of a model system that contains full trisomy of chromosome 21 (Ts21...
ORGANISM(S): Homo sapiens 
2013-07-09 | E-GEOD-48611 | biostudies-arrayexpress
MetabolomicsSymbiotic bacteria-derived organic acids protect Delia antiqua larvae from entomopathogenic fungal infection

The protection of associated microbiota for their animal hosts against pathogen infection has been studied widely over the last 100 years. However, how those microbes protect the animal host is limitedly investigated. In former studies, body surface microbes of one insect, Delia antiqua,...

2020-11-12 | MTBLS2074 | MetaboLights
TranscriptomicsIkaros mutation confers integrin-dependent pre-B cell survival and progression to acute lymphoblastic leukemia
Deletion of the Ikaros DNA-binding domain generates dominant-negative isoforms that interfere with Ikaros family activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemias (B-ALL).  Here, we show that conditional inactivation of the Ikaros DNA binding domain i...
ORGANISM(S): Mus musculus 
2014-02-09 | E-GEOD-53401 | biostudies-arrayexpress
MetabolomicsMetabolomic profiling of colon tissue in loperamide-induced constipation mice treated with Rothia mucilaginosa

Untargeted metabolomics was performed on colon tissue from 26 C57BL/6 mice to investigate metabolic mechanisms underlying Rothia mucilaginosa-mediated constipation alleviation. Mice were divided into normal control (NC, n=8), loperamide-induced constipation model control (MC, n=8), and R. mucilag...

2026-04-27 | MTBLS13907 | MetaboLights
UnknownDevelopment and Validation of a Polygenic Risk Score for Stroke in the Chinese Population.
Not available
S-EPMC8424497 | biostudies-literature
TranscriptomicsTranscriptome sequencing of naked mole rat, Heterocephalus glaber
Deep sequencing of mRNA from naked mole rat Analysis of ploy(A)+ RNA of different specimens: brain, kidney, liver from new born , 4 years old , 20 years old and 4 years old hypoxia-exposed naked mole rat
ORGANISM(S): Heterocephalus glaber 
2011-10-12 | E-GEOD-30337 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Bone-Marrow-Derived-Macrophages (5 days of culture) in a backcross population of LEW and WKY
WKY and LEW strains have been widely studied for their differential susceptibility to experimental glomerulonephritis. In particular these strains show strong variations in the macrophage activation. This dataset measures expression of macrophages in backcross population of WKY DC and LEW rats and ...
ORGANISM(S): Rattus norvegicus 
2014-08-31 | E-MTAB-2719 | biostudies-arrayexpress
ProteomicsTMT-based Proteomic analysis of licorice root in response to drought stress
Drought stress is a serious threat to land use efficiency and crop yields worldwide. Understanding the mechanisms that plants use to withstand drought stress will help breeders develop drought-tolerant medicinal crops. We used an integrated approach of Tandem Mass Tag labeling in conjunction with LC...
ORGANISM(S): Glycyrrhiza Uralensis 
2022-04-30 | PXD033656 |
TranscriptomicsA robust single primate neuroepithelial cell clonal expansion system for neural tube development and disease studies
Developing a model of primate neural tube (NT) development is important to promote many NT disorder studies in model organisms. Here, we report a robust and stable system to allow for clonal expansion of single monkey neuroepithelial stem cells (NESCs) to develop into miniature NT-like structures. S...
ORGANISM(S): Macaca mulatta 
2015-11-21 | E-GEOD-73892 | biostudies-arrayexpress
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