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ProteomicsPHACTR1, a coronary artery disease risk gene, drives endothelial dysfunction
Recent genome-wide association studies have identified PHACTR1 as a critical risk gene associated with polyvascular diseases. However, it remains elusive how PHACTR1 is involved in endothelial dysfunction. Here, we show that PHACTR1 triggers endothelial inflammation by activating NF-κB and disrupts ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-16 | PXD034213 | Pride
Endothelial dysfunction  inflammation  phactr1  nitric oxide  innate immunity  coronary artery disease 
ProteomicsResearch on the progression and treatment resistance mechanism of liver cancer
Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by rapid progression, therapeutic resistance, and poor prognosis. This project aims to investigate the molecular mechanisms underlying HCC development and progression, with a particular focus on signaling pathways that re...
ORGANISM(S): Homo Sapiens 
2025-12-23 | PXD072376 |
ProteomicsCRISPR-Assisted Detection of RNA-Protein Interactions in Living Cells
We develop a CRISPR-Assisted RNA-Protein Interaction Detection method (CARPID), which leverages CRISPR/CasRx-based RNA targeting and proximity labeling to identify binding proteins of specific lncRNA in the native cellular context.
ORGANISM(S): Homo Sapiens 
2020-05-20 | PXD015702 |
ProteomicsIL-33 stabilizes the transcription factor IRF1
Interleukin-33 (IL-33) functions both as a secreted cytokine and as a nuclear factor, with pleiotropic roles in tumor growth and immunity. Here, we explored its role in hepatocellular carcinoma (HCC) and identified that its nuclear function mediated a mechanism of immune escape.
ORGANISM(S): Homo Sapiens 
2022-12-28 | PXD039110 |
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