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UnknownDiscovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase.
Not available
S-EPMC6274076 | biostudies-literature
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
ProteomicsTudor-based Proteomic Strategy Pan-specifically Enriches and Identifies Protein Arginine Methylation
In current study, we developed a molecular affinity strategy based on the Tudor domain of SMN, a naturally occurring methylarginine reader protein, for comprehensive proteomic profiling of cellular arginine methylation. We demonstrated that the Tudor domain-based approach exhibits broad specificity ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD053390 | Pride
Proteomics Arginine methylation Molecular affinity-enrichment method Eif3d 
UnknownVerruculosins A-B, New Oligophenalenone Dimers from the Soft Coral-Derived Fungus Talaromyces verruculosus.
Not available
S-EPMC6780165 | biostudies-literature
ProteomicsMouse Cardiac Proteomics and β-hydroxybutyrylation omics Studies
β-Hydroxybutyrylation (kbhb) is a new type of post-translational modification(PTM) of lysine acylation. In recent years, kbhb modification has been shown to be involved in energy metabolism, tumor metabolism, DNA damage repair and other processes. Currently, lysine β-hydroxybutyrylation has not ...
ORGANISM(S): Mus Musculus 
2023-03-14 | PXD034269 |
ProteomicsSpecific sDMA Modifications on the RGG/RG Motif of METTL14 Regulate Its Function in AML
Protein arginine methylations are crucial post-translational modifications (PTMs) in eukaryotes, playing a significant regulatory role in diverse biological processes. Different forms of arginine methylations are known to co-exist within densely modified arginine-rich protein regions. However, pinpo...
ORGANISM(S): Homo Sapiens 
PXD054570 |
ProteomicsTRIM55 promotes noncanonical NF-kB signaling and B-cell-mediated immune responses by coordinating p100 ubiquitination and processing
The ubiquitination-dependent processing of NF-B2 (also known as p100) is a critical step in the activation of the noncanonical NF-B pathway. We investigated the molecular mechanisms regulating this process and showed that TRIM55 was the ubiquitin E3 ligase that mediated the ubiquitination of p100 ...
ORGANISM(S): Mus Musculus 
PXD044895 |
ProteomicsDeciphering the clinical significance and kinase functions of GSK3α in colon cancer by proteomics and phosphoproteomics
In this study, paired tumors and distant normal tissues (DNTs) collected from 78 treatment-naïve colon cancer patients were subjected to tandem mass tag (TMT)-based proteomics. We found that the expression of GSK3α, but not GSK3β, was significantly correlated with the overall survival (OS) of colon ...
ORGANISM(S): Homo Sapiens 
2023-03-03 | PXD038830 |
ProteomicsIntegrative omics reveals magnesium deficiency as a driver factor of colorectal cancer
Magnesium (Mg) deficiency is associated with increased risk and malignancy of colorectal cancer (CRC), but the underlying mechanisms remain elusive. In our study, we used genomic, proteomic, and phosphoproteomic data to reveal the effects of low Mg content on genomic instability and tumor metastasis...
ORGANISM(S): Homo Sapiens 
PXD042746 |
ProteomicsLow-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut
we developed a low-input and user-friendly pipeline for the simultaneous profiling of five distinct Cys states with regional resolution in the gut of monkeys, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S-nitrosylation (SNO), and S-glutathionylation (SSG), shedding light on re...
ORGANISM(S): Macaca Fascicularis Fascicularis Homo Sapiens Mus Musculus 
2024-12-16 | PXD053818 |
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