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TranscriptomicsDiscovery of novel and conserved microRNAs in Spirodela polyrhiza by deep sequencing
MicroRNAs (miRNAs) are a class of small, endogenous non-coding RNAs, which play key roles in a variety of developmental and physiological processes by regulating gene expressions at post-transcriptional or translational levels. The objective of our work was to explore conserved and novel miRNAs in S...
ORGANISM(S): Spirodela polyrhiza 
2014-02-21 | E-GEOD-55208 | biostudies-arrayexpress
MetabolomicsThe Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
B7H3 (also known as CD276) is a co-stimulator checkpoint protein of the cell surface B7 superfamily. Recently, the function beyond immune regulation of B7H3 has been widely studied. However, the expression preference and the regulation mechanism underlying B7H3 in different subtypes of gliomas is ra...
2021-05-26 | MTBLS2692 | MetaboLights
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
UnknownGSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions.
Not available
S-EPMC6251088 | biostudies-literature
UnknownImmunohistochemistry Study of OY-TES-1 Location in Fetal and Adult Human Tissues.
Not available
S-EPMC9020931 | biostudies-literature
ProteomicsProfiling Glutathionylome in CD38-mediated Epithelial-Mesenchymal Transition
We engineered a cell system in which the glutathione synthetase (GS) mutant was expressed that catalyzed the formation of a glutathione analogy from azido-alanine to profile changes of glutathionylome in CD38-overexpressing cells.
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD032233 | Pride
Cd38 glutathionylome epithelial-mesenchymal transition 
ProteomicsBLM-G4 pulldown IP-MS in human colon cancer HT-29 cells
the experiment uses biotin-labelled BLM-G4 to incubate with HT-29 cell lysates, and uses streptavidin agarose beads to pulldown BLM-G4-binding proteins. Utilize LC-MS/MS to annotate and quantify the proteins pulled down by BLM-G4.
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD075345 | Pride
Pulldown Blm-g4 Ip-ms Ht-29 cell 
UnknownA two-sample Mendelian randomization study of type 1 diabetes and the risk of 22 site-specific cancers.
Not available
S-EPMC11965372 | biostudies-literature
GenomicsSequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk
Cross-talk between DNA methylation and histone modifications drives the establishment of composite epigenetic signatures and is traditionally studied using correlative rather than direct approaches. Here we present sequential ChIP-bisulfite-sequencing (ChIP- BS-seq) as an approach to quantitatively ...
ORGANISM(S): Homo sapiens 
2012-03-27 | E-GEOD-28254 | biostudies-arrayexpress
Genomicsena-DATASET-BGI-18-06-2015-05:57:10:511-19 - samples
We sequenced 205 patients who were suffering NSCLC with Exome sequencing method.
EGAD00001001398 | EGA
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