GalNAc-T2 was identified as a novel antiviral factor that promotes viral clearance and contributes to reduced disease severity.This project aimed to investigate the impact of GalNAc-T2 overexpression on proteomics and glycoproteomics in lung cell. We employ SILAC labeling, lectin-based affinity enri...
Gypenosides is a traditional drug for the treatment of metabolic disorders. Recent studies have confirmed its anti-nonalcoholic fatty liver disease (NAFLD) effects, but the underlying mechanisms are still not fully understood. The purpose of this study was to explore the protective mechanism of gype...
Beta-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder primarily caused by mutations in the WD repeat domain 45 (WDR45) gene. While WDR45 has traditionally been linked to autophagy, our study uncovers a previously unrecognized role for WDR45 as a cri...
Polysaccharides are traditionally confined to the cell surface and extracellular space, whereas their nuclear roles remain unclear. Here, we show that N-glycans are present in the nucleus and modify inner nuclear membrane (INM) proteins across multiple cell types. Disruption of INM protein N-glycosy...
liquid chromatography tandem mass spectrometry is used to identificate of the circEZH2_005-Interacting protein pulled down by circEZH2_005 junction probe with protein extracts from Intestinal crypt cells.
