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GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
ProteomicsCrosstalk between cell wall-sensing and hormone-sensing receptor kinases regulates plant cell elongation
Plant cell elongation change in its rate during day and night alteration, reflecting differences in metabolism and involving cell wall remodeling that typically determine the rate and direction of cell expansion. How signal transduction is initiated by the cell wall remains elusive. Here, we show th...
ORGANISM(S): Oryza Sativa Escherichia Coli 
2022-02-08 | PXD031504 |
ProteomicsThe potential binding proteins of FOXQ1 were detected by mass spectrometry technology, laying the foundation for the subsequent in-depth study of its molecular mechanism
First, Flag-FOXQ1 was overexpressed in HCT-116 cells. Subsequently, the Flag-FOXQ1 complex was enriched via immunoprecipitation (IP) technology. The complex was then washed four times with phosphate-buffered saline (PBS), denatured in loading buffer by boiling, and separated via gel electrophoresis ...
ORGANISM(S): Homo Sapiens 
2025-06-09 | PXD064807 |
ProteomicsO-glycosylation in fruit development and ripening
O-glycosylation is a critical post-translational modification (PTM) regulating protein function, yet its role in plant transcription factors remains poorly understood.
ORGANISM(S): Solanum Lycopersicum 
2025-12-16 | PXD072030 |
ProteomicsSimultaneous deep transcriptome and proteome profiling in single mouse oocytes
Deep proteome data in the single-cell multi-omics analysis of single mouse oocytes.
ORGANISM(S): Mus Musculus 
2023-10-17 | PXD043935 |
ProteomicsSpatial-region-resolved proteomic map reveals mechanism of COVID-19-associated heart injury
Coronavirus disease 2019 (COVID-19) induces diverse clinical manifestations accompanied by multi-organ dysfunction. Of these, heart complications are the most life threatening. Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drive systemic ...
ORGANISM(S): Homo Sapiens 
2022-01-26 | PXD031249 |
ProteomicsPick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a tumor cell
The shotgun proteomic analysis is currently the most promising single-cell protein sequencing technology, however its identification level of ~1000 proteins per cell is still insufficient for practical applications. Here, we develop a pick-up single-cell proteomic analysis (PiSPA) workflow to achiev...
ORGANISM(S): Homo Sapiens 
2023-10-30 | PXD041966 |
ProteomicsHK1 from HSC-derived extracellular vesicles promotes HCC progression
Extracellular vesicles play crucial roles in intercellular communication in tumor microenvironment. Here, we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which facilitates the secretion of HK1 via large extracellula...
ORGANISM(S): Homo Sapiens 
2022-08-09 | PXD035911 |
ProteomicsLarge-scale and high-resolutionmass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting
Esophageal cancer (EC) is anaggressive cancer type without clinically relevant molecular subtypes defined, which hinders the development of effective strategies forEC treatment. Here, we reporteda large-scale, high-resolution massspectrometry-based proteomicand phosphoproteomics profiling of EC tumo...
ORGANISM(S): Trichuris Sp. Ex Homo Sapiens Jp-2011 
2021-07-05 | PXD021701 |
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