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ProteomicsAKT/PACS2 participates in renal vascular hyperpermeability by regulating endothelial fatty acid oxidation in diabetic mice
HUVECs were purchased from the American Type Culture Collection (ATCC, Manassas, VA, USA) and cultured in an Endothelial Cell Medium (Invitrogen, Carlsbad, CA, USA) containing 5% fetal bovine serum at 37°C in a 5% CO2 incubator. Cells were treated with 30 mM glucose and 0.1 mM palmitic acid (P0500, ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD033227 | Pride
Pacs2 Diabetes Endoplasmic reticulum Mitochondria Fatty acid oxidation Endothelial cell Vascular permeability 
UnknownFood as medicine: A possible preventive measure against coronavirus disease (COVID-19).
Not available
S-EPMC7283886 | biostudies-literature
UnknownSwimming exercise is a promising early intervention for autism-like behavior in Shank3 deletion rats.
Not available
S-EPMC9804047 | biostudies-literature
MetabolomicsThe Kalanchoe genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism
Crassulacean acid metabolism (CAM) is a water-use efficient adaptation of photosynthesis that has evolved independently many times in diverse lineages of flowering plants. We hypothesize that convergent evolution of protein sequence and temporal gene expression underpins the independent emergences o...
2018-01-09 | MTBLS519 | MetaboLights
GenomicsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila
We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
2015-11-02 | E-GEOD-63011 | biostudies-arrayexpress
ProteomicsTargeting WTX-P54nrb Phase Separation Sensitizes Chemotherapy in Gastric Cancer
To provide insights into any distinctions between the cellular functions of WTX-S and WTX-L, we defined their protein interaction networks by performing liquid chromatography–tandem MS of affinity-purified protein complexes.
ORGANISM(S): Homo Sapiens 
PXD057127 |
ProteomicsUsing proteomics and transcriptomics to explore the potential gene regulatory network of immune checkpoint inhibitors-related myocarditis
Immune checkpoint inhibitor-related myocarditis is the deadliest complication of immunotherapy. However, the underlying pathophysiological mechanisms of its occurrence and development remain unclear. Due to the long-term lack of effective early diagnosis and treatment options, it is of great signifi...
ORGANISM(S): Homo Sapiens 
2023-02-02 | PXD039793 |
ProteomicsOrganization, genomic targeting and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis
To comprehensively define the potential plant SWI/SNF sub-complexes and their subunits organization, we started by performing immuno-purification followed by mass spectrometry analysis (IP-MS) using stable transgenic Arabidopsis lines that expressed a green fluorescent protein (GFP)-tagged ATPase su...
ORGANISM(S): Arabidopsis Thaliana 
PXD041567 |
ProteomicsBCL7A and BCL7B potentiate SWI/SNF-complex-mediated chromatin accessibility to regulate gene expression and vegetative phase transition in Arabidopsis
Arabidopsis thaliana, 14-day-old seedlings grow in 1/2 MS culture medium under short day condition, LC-MS. In this project, two different materials (One is in the wild type background, the other is in the mutant background.) were used to do CoIP experiments, and then mass spectrometry was carried ou...
ORGANISM(S): Arabidopsis Thaliana 
2024-01-03 | PXD045757 |
ProteomicsSpin-driven Enantioselective Regulation of Cyclooxygenase-2 Activity for Rheumatoid Arthritis Therapy via Chiral Gold Nanohelices
Electron-spin dynamics represent an unexplored dimension in enzymatic catalysis, where most regulatory strategies focus on modulating active-site chemistry. Here, we present a spintronic approach that employs chiral gold nanohelices (CAu) as electron spin polarizers to enantiospecifically modulate c...
ORGANISM(S): Mus Musculus 
PXD076742 |
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