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ProteomicsBeclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis
Becn1 deficiency in the megakaryocytic lineage reduces sex hormone-binding globulin (SHBG), thus releasing testosterone into the blood and ultimately leading to increased bone mass and improved bone quality.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058230 | Pride
Mouse Bone homeostasis Beclin1 
ProteomicsBeclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival
Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism is poorly understood. Here, we show that under physiological conditions, inactivation of ISG15, an inflammation amplifier, is associated with the interaction of Beclin 1 (Becn1), via its ECD...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD057003 | Pride
Beclin 1 Mouse Fetal liver 
ProteomicsIntegrated proteomic and N-glycoproteomic profiling of placental tissues of patients with preeclampsia
Integrated proteomic and N-glycoproteomic profiling of placental tissues of patients with preeclampsia
ORGANISM(S): Homo Sapiens 
2022-03-14 | PXD032286 |
ProteomicsProteomics and metabonomics analyses of Covid-19 complications in patients with pulmonary fibrosis
Pulmonary fibrosis is a devastating disease, and the pathogenesis of this disease is not completely clear. Here, the medical records of 85 Covid-19 cases were collected, among which fibrosis and progression of fibrosis were analyzed in detail. Next, data independent acquisition (DIA) quantification ...
ORGANISM(S): Homo Sapiens 
2021-02-22 | PXD024311 |
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