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UnknownStable GaSe-Like Phosphorus Carbide Monolayer with Tunable Electronic and Optical Properties from Ab Initio Calculations.
Not available
S-EPMC6213067 | biostudies-literature
ProteomicsUSP9X coordinates TGF-β and hypoxia signalings to promote ovarian cancer chemoresistance via maintaining cancer stem cells
Widespread intraperitoneal metastases and chemoresistance has made ovarian cancer the leading cause of gynecological malignancy–related deaths, wherein TGF-β signaling plays the pivotal role by promoting cancer stem cells (CSCs) activity. Whereas, how the signaling is activated and how to target TGF...
ORGANISM(S): Homo Sapiens 
2024-03-08 | PXD050476 |
UnknownDesign, synthesis and evaluation of anti-CD38 antibody drug conjugate based on Daratumumab and maytansinoid.
Not available
S-EPMC6339845 | biostudies-literature
ProteomicsA Tissue-Specific Atlas of Mouse N-Glycoproteome
In this study, we employed StrucGP to generate the first high-resolution and site-specific N- glycoproteomic atlas across 24 diverse mouse tissues. This comprehensive dataset provides an unprecedented insight into the tissue-specific landscape of N-glycosylation, revealing how distinct glycan struct...
ORGANISM(S): Mus Musculus 
PXD063701 |
MetabolomicsLipidomic profiling reveals distinct differences in plasma lipid composition in healthy, prediabetic and type 2 diabetic individuals

The relationship between dyslipidemia and type 2 diabetes mellitus (T2D) has been extensively reported, but the global lipid profiles, especially in the East Asia population, associated with the development of T2D remain to be characterized. Liquid chromatography coupled to tandem mass spectromet...

2017-04-26 | MTBLS352 | MetaboLights
ProteomicsQuantitative glycoproteomic, proteomic, and phosphoproteomic analysis of aged mouse ovary
In this work, we investigate the differences of site-specific N-glycosylation between young (2-month-old) and middle-aged (12-month-old) mouse ovarian tissues by integrating N-glycoproteomics and proteomic approaches with tandem mass tag (TMT) labeling.To identify signalling pathways associated with...
ORGANISM(S): Mus Musculus 
PXD056126 |
ProteomicsHypoxia Regulates Overall mRNA Homeostasis by Inducing Met1-linked Linear Ubiquitination of AGO2 in Cancer Cells
Hypoxia is the most prominent feature in human solid tumors and induces activation of hypoxia-inducible factors and their downstream genes to promote cancer progression. However, whether and how hypoxia regulates overall mRNA homeostasis is unclear. Here we show that hypoxia inhibits global-mRNA dec...
ORGANISM(S): Homo Sapiens 
PXD021722 |
ProteomicsThe BPAN disease protein WDR45 forms condensates with Caprin-1 to regulate stress granule disassembly
Beta-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder primarily caused by mutations in the WD repeat domain 45 (WDR45) gene. While WDR45 has traditionally been linked to autophagy, our study uncovers a previously unrecognized role for WDR45 as a cri...
ORGANISM(S): Homo Sapiens 
PXD062911 |
ProteomicsHuman iTRAQ biological information analysis
Screening of differentially expressed proteins;Bioinformatics analysis of differentially expressed proteins;
ORGANISM(S): Homo Sapiens 
2020-10-28 | PXD022209 |
ProteomicsQuantitative proteomics profilling of p62 droplet
Phase separated p62 body plays pivotal roles during autophagosome formation, however, the underlying mechanisms are still not fully understood. Mass spectrometry-based proteomics revealed significant enrichment of vesicle trafficking components within p62 bodies.
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2023-06-09 | PXD038262 |
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