Sort   by:  
 Page size 
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
ProteomicsSARS-CoV-2 ORF8 interactome in the secretory pathway
The replication machinery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely associated with the endoplasmic reticulum (ER) in host cells. Activation of the unfolded protein response (UPR) is a strategy hijacked by coronavirus to facilitate its replication and suppress ho...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032035 | Pride
Orf8 2-d gel Endoplasmic reticulum Lc-ms/ms 
ProteomicsInhibition of a novel CLK1-THRAP3-PPARγ axis improves insulin sensitivity
CLK1 plays a critical role in controlling energy expenditure through the CLK1-Thrap3-PPARγ axis.
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD027958 |
ProteomicsProteomics of obstructed kidneys from patients with obstructive nephropathy and unilateral ureteral obstruction mice
Here, we performed proteomics of kidneys obtained from patients with obstructive nephropathy and healthy controls (n=11/8), or from unilateral ureteral obstruction (UUO) mice and sham mice (n=6/6). Proteomic measurement of all human kidney samples resulted in a total of 6089 proteins with an average...
ORGANISM(S): Homo Sapiens Mus Musculus 
2023-01-08 | PXD039314 |
ProteomicsModulation of Microbial Bile Acid Metabolism by DT-109 Ameliorates Nonalcoholic Steatohepatitis in Nonhuman Primates
Modulation of Microbial Bile Acid Metabolism by DT-109 Ameliorates Nonalcoholic Steatohepatitis in Nonhuman Primates
ORGANISM(S): Macaca Fascicularis Fascicularis 
2023-02-10 | PXD040009 |
Sort   by:  
 Page size