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ProteomicsIntegrating metabolic and evolutionary engineering for enhanced propionic acid production under cross stress: a multi-omics perspective
We performed a combination of metabolic engineering (deletion of ldh and poxB and overexpression of mmc) with evolutionary engineering (selection under oxygen stress, acid stress and osmotic stress) in Propionibacterium acidipropionici. The results indicated that the mutants had superior physiologic...
ORGANISM(S): Acidipropionibacterium acidipropionici 
2020-04-27 | PXD016616 | Pride
Omics analysis Cross stress Metabolic and evolutionary engineering Propionibacterium acidipropionici Propionic acid 
Transcriptomicsrice ssRNA-seq
We took advantage of ssRNA-seq technology to deeply sequence mRNAs of the model plant species Oryza sativa ssp.japonica cv Nipponbare with clear transcriptional orientations for assessing rice cis-NATs at the best possible resolution. We also deeply sequenced rice small RNAs from the same tissues as...
ORGANISM(S): Oryza sativa Japonica Group 
2011-12-28 | E-MTAB-721 | biostudies-arrayexpress
ProteomicsHBXIP-mediated cell cycle, apoptosis and autophagy participate in the inhibitory effect of Germacrone on gastric cancer cells
As a monocyclic sesquiterpene, Germacrone has remarkable anti-tumor effect in a variety of cancers such as hepatocellular carcinoma, gastric cancer, and breast cancer. However, the mechanism of Germacrone on gastric cancer was still unclear. In our study, Germacrone inhibited gastric cancer cells pr...
ORGANISM(S): Homo Sapiens 
2020-10-14 | PXD021980 |
ProteomicsIdentification of key factors in cartilage tissue during the progression of osteoarthritis using a non-targeted metabolomics strategy
This work used non-targeted metabolomics and screened out differential metabolites and metabolic pathways, providing a reliable theoretical basis for further study of specific markers and their specific pathways in the progression of OA.
ORGANISM(S): Homo Sapiens 
2023-04-02 | PXD041287 |
ProteomicsLibrary-Based, Multiplexed Strategy for Mapping Protein Interaction Networks via Crosslinking
Protein-protein interactions are fundamental to cellular function, yet resolving their interaction interfaces and dynamic behaviors in native biological contexts remains challenging, particularly for weak or transient interactions. Crosslinking strategies based on noncanonical amino acids offer an e...
ORGANISM(S): Homo Sapiens 
2026-02-28 | PXD075032 |
ProteomicsSOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in HCC
SOCS5 stimulate the promoter of SREBP1 to induce de novo lipogenesis to promote HCC metastasis
ORGANISM(S): Homo Sapiens 
2024-01-22 | PXD048740 |
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
ProteomicsSubcommissural organ (SCO) contributes to brain development via SCO-secreted peptides
To explore the role of SCO and its functional mechanism, we measure the SCO-derived peptide in CSF from C57B/6 mice and SCO-ablated mice.
ORGANISM(S): Mus Musculus 
2025-02-04 | PXD040641 |
ProteomicsProteins that interaction with SCARB2 in HCCLM3 cells and analysis of acetylation site of MYC in SCARB2-overexpressing HCCLM3 cells
Quantitative mass spectrometry (MS)-based proteomics to assess acetylation modification of MYC in HCCLM3 cells with SCARB2 overexpression and analysis of SCARB2 immunoprecipitates in HCCLM3 cells.
ORGANISM(S): Homo Sapiens 
2023-08-12 | PXD044544 |
ProteomicsA quantitative proteomic study reveals oxidative stress and synaptic loss contributed to TDCIPP exposure induced memory impairment (2)
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been consistently identified in various environmental media and biological specimens. The current understanding of the in vivo toxicities of TDCIPP remains limited, especially for its neurotoxicity and cognitive impairment effects. To better evaluat...
ORGANISM(S): Rattus Rattus 
2023-10-08 | PXD045959 |
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