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ProteomicsIntegrating metabolic and evolutionary engineering for enhanced propionic acid production under cross stress: a multi-omics perspective
We performed a combination of metabolic engineering (deletion of ldh and poxB and overexpression of mmc) with evolutionary engineering (selection under oxygen stress, acid stress and osmotic stress) in Propionibacterium acidipropionici. The results indicated that the mutants had superior physiologic...
ORGANISM(S): Acidipropionibacterium acidipropionici 
2020-04-27 | PXD016616 | Pride
Omics analysis Cross stress Metabolic and evolutionary engineering Propionibacterium acidipropionici Propionic acid 
Transcriptomicsrice ssRNA-seq
We took advantage of ssRNA-seq technology to deeply sequence mRNAs of the model plant species Oryza sativa ssp.japonica cv Nipponbare with clear transcriptional orientations for assessing rice cis-NATs at the best possible resolution. We also deeply sequenced rice small RNAs from the same tissues as...
ORGANISM(S): Oryza sativa Japonica Group 
2011-12-28 | E-MTAB-721 | biostudies-arrayexpress
ProteomicsIdentification of key factors in cartilage tissue during the progression of osteoarthritis using a non-targeted metabolomics strategy
This work used non-targeted metabolomics and screened out differential metabolites and metabolic pathways, providing a reliable theoretical basis for further study of specific markers and their specific pathways in the progression of OA.
ORGANISM(S): Homo Sapiens 
2023-04-02 | PXD041287 |
ProteomicsLibrary-Based, Multiplexed Strategy for Mapping Protein Interaction Networks via Crosslinking
Protein-protein interactions are fundamental to cellular function, yet resolving their interaction interfaces and dynamic behaviors in native biological contexts remains challenging, particularly for weak or transient interactions. Crosslinking strategies based on noncanonical amino acids offer an e...
ORGANISM(S): Homo Sapiens 
2026-02-28 | PXD075032 |
ProteomicsSubcommissural organ (SCO) contributes to brain development via SCO-secreted peptides
To explore the role of SCO and its functional mechanism, we measure the SCO-derived peptide in CSF from C57B/6 mice and SCO-ablated mice.
ORGANISM(S): Mus Musculus 
2025-02-04 | PXD040641 |
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
2024-06-22 | PXD053334 |
ProteomicsProteins that interaction with SCARB2 in HCCLM3 cells and analysis of acetylation site of MYC in SCARB2-overexpressing HCCLM3 cells
Quantitative mass spectrometry (MS)-based proteomics to assess acetylation modification of MYC in HCCLM3 cells with SCARB2 overexpression and analysis of SCARB2 immunoprecipitates in HCCLM3 cells.
ORGANISM(S): Homo Sapiens 
2023-08-12 | PXD044544 |
ProteomicsA quantitative proteomic study reveals oxidative stress and synaptic loss contributed to TDCIPP exposure induced memory impairment (2)
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) has been consistently identified in various environmental media and biological specimens. The current understanding of the in vivo toxicities of TDCIPP remains limited, especially for its neurotoxicity and cognitive impairment effects. To better evaluat...
ORGANISM(S): Rattus Rattus 
2023-10-08 | PXD045959 |
ProteomicsLRRC71 is essential for sperm motility, fertilization and male fertility
Although sperm supply half the genomic material necessary for generating viable offspring in sexual reproduction, the core molecular mechanisms underlying their formation remain largely unelucidated. Here, we demonstrate that leucine-rich repeat-containing 71 (LRRC71) is essential for spermatogenesi...
ORGANISM(S): Mus Musculus 
2026-04-29 | PXD077837 |
ProteomicsHistone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting
To look for factors that may have preferential binding to H3S28ph and mediate the stimulation to gene expression.
ORGANISM(S): Mus Musculus 
2022-05-25 | PXD034125 |
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