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Proteomicssystematic proteomic of 20 cases of primary ESCC tumor tissue (T), matched normal tissue (N) and lymph node metastatic tissue (LN)
To obtain the global landscape of Khib in ESCC metastasis, 20 cases of primary ESCC tumor tissue (T), matched normal tissue (N) and lymph node metastatic tissue (LN) were subjected to systematic proteomic.
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD037295 | Pride
Proteomics Cancer metastasis 
ProteomicsDysregulation of phophoproteins in hepatocellular carcinoma revealed by the quantitative analysis of phosphoproteome
Hepatocellular carcinoma is one of the most frequently diagnosed cancers in the world. Post-translational modifications (PTMs) play an essential role during cancer development. Phosphorylation is an important PTMs. To identify the modifications of phosphorylation in HCC, a multiplexed tandem mass ta...
ORGANISM(S): Homo sapiens (Human) 
2021-01-14 | PXD013934 | Pride
Hepatocellular carcinoma Lc−ms/ms Phophoproteins 
ProteomicsProteomics reveals the inhibitory mechanism of Levodopa against esophageal squamous cell carcinoma
The high recurrence rate and poor survival prospects of esophageal squamous cell carcinoma (ESCC) patients after treatment make the ongoing research on chemoprevention drugs for ESCC particularly important. In helping to solve this problem, we screened a large number of FDA-approved drugs and found ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013824 | Pride
Mitochondria Levodopa Chemoprevention Esophageal squamous cell carcinoma (escc) 
MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
ProteomicsLysine 2-hydroxyisobutyrylatome profiling reveals extensive lysine 2-hydroxyisobutyrylation in common wheat
In this work, we first analyzed wheat (Triticum aestivum L.) lysine Khib sites by mass spectrometry. A total of 3,348 lysine modification sites from 1,047 proteins were identified in wheat seedlings. The identified Kcr proteins were discovered to be widespread. Bioinformatic data indicated these Kcr...
ORGANISM(S): Triticum aestivum (Wheat) 
2022-12-31 | PXD012666 | Pride
Triticum aestivum l.  post-translational modification  lysine 2-hydroxyisobutyrylation  mass spectrometry  function 
ProteomicsGeneration of multi-disease spectral library
We created a multi-disease spectral library using 100 serum samples obtained from five patient groups, including healthy controls (n=20), Bechet's disease (n=20), non-small cell lung cancer (n=20) and liver diseases (n=20). The multi-disease spectral library included a total of 9,104 precursors and...
ORGANISM(S): Homo Sapiens 
2023-03-06 | PXD040603 |
ProteomicsNovel molecular glue degraders against broad range of myeloma and lymphoma cancer cell lines
Targeted protein degradation of neosubstrates plays a crucial role in treating hematological cancers with IMiDs therapy. However, the inevitable drug resistance and hematological toxicities remain persistent challenges, limiting their clinical efficacy. Herein, we present the discovery of a lead deg...
ORGANISM(S): Homo Sapiens 
PXD053334 |
UnknownMortality and Morbidity in Adults With Rheumatic Heart Disease.
Not available
S-EPMC11154374 | biostudies-literature
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