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ProteomicsSequential release of interacting proteins and Ub-modifying enzymes by disulfide heterotypic ubiquitin reagents
Heterotypic ubiquitin (Ub) chains have emerged as fundamental components in a wide range of cellular processes. The integrative identification of Ub-interacting proteins (readers) and Ub-modifying enzymes (writers and erasers) that selectively recognize and regulate heterotypic ubiquitination may pr...
ORGANISM(S): Saccharomyces Cerevisiae 
2023-09-28 | PXD045936 |
Proteomicsputative K29-linked substrates identification using sAB-K29
We have identified K29-linked ubiquitination is involved in cell cycle regulation and enriched in midbody formation. To identify the substrates of K29-linked ubiquitination in the midbody, we soughtto perform immunoprecipitation (IP) under denaturing conditions to minimize the presence of noncovalen...
ORGANISM(S): Homo sapiens (Human) 
2021-07-11 | PXD024425 | Pride
K29-linked ubiquitination 
ProteomicsStage-specific, morphological and molecular markers of encystation in Giardia lamblia
Differentiation into environmentally resistant cysts is required for transmission of the ubiquitous intestinal parasite Giardia lamblia. Encystation in Giardia requires the production, processing and transport of Cyst Wall Proteins (CWPs) in stage induced Golgi-like Encystation Specific Vesicles (ES...
ORGANISM(S): Giardia lamblia ATCC 50803 
2021-07-11 | PXD024428 | Pride
Rho gtpase Giardia Membrane trafficking Rac Encystation 
UnknownAssociation between Elevated Magnesium Intake and Reduced Risk of Recurrent Falls and Frailty in Osteoarthritis: Data from the Osteoarthritis Initiative.
Not available
S-EPMC12275575 | biostudies-literature
UnknownUSP4-mediated CENPF deubiquitylation regulated tumor metastasis in colorectal cancer.
Not available
S-EPMC11807140 | biostudies-literature
ProteomicsStructure-guided development of chemically tailored peptide binders of RNF43/ZNRF3 to enable versatile design of membrane protein-targeting PROTACs
Targeted membrane protein degradation using cell surface E3 ligases RNF43/ZNRF3 via proteolysis targeting chimeras (PROTACs) represents an effective strategy for treating membrane drug targets that cannot be fully inhibited using traditional inhibitors. Several ingenious chimeras have been developed...
ORGANISM(S): Homo Sapiens 
2025-03-04 | PXD061425 |
ProteomicsThe influence of IL-1β and TNF-α on the tenogenic differentiation of human periodontal ligament stem cells via global proteomic analysis
The hPDLSCs were cultured in the tenogenic medium treated with 0.1 ng/ml IL-1β or 10 ng/ml TNF-α for 7 days. Total proteins were isolated from the collected cell samples. Subsequently, the LFQ-based proteomic analysis was conducted for the extracted proteins in each group as established procedures...
ORGANISM(S): Homo Sapiens 
2024-10-05 | PXD056585 |
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