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TranscriptomicsComparison of gene expression profiles in naïve WT and Asc-null bone marrow derived dendritic cells
The adaptor protein ASC contributes to innate immunity through the assembly of caspase-1-activating inflammasome complexes. We demonstrate that ASC plays an inflammasome-independent cell-intrinsic role in adaptive immune cells. Asc-/- mice displayed defective antigen presentation by dendritic cells ...
ORGANISM(S): Mus musculus 
2012-07-08 | E-GEOD-30769 | biostudies-arrayexpress
ProteomicsThe Rac-GEF Tiam1 controls integrin-dependent neutrophil responses
Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav and Dock families. In this study, we demonstrate that Tia...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD046791 | Pride
Tiam1 Dock2 Vav Neutrophils Rac Prex1 Rac-gef Small gtpase 
ProteomicsA Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia...
3xFLAG-IPs from HEK293T cell lysates expressing 3xFLAG-bait or 3xFLAG-control. Trypsin Digestion
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-09 | MSV000079100 | MassIVE
TranscriptomicsEfficient direct reprogramming of c-Kit− mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression
ETS transcription factors ETV2, FLI1 and ERG1 specify pluripotent stem cells into endothelial cells (PSC-ECs). However, these PSC-ECs are unstable and often drift towards non-vascular cell fates. We show that human mid-gestation c-Kit- lineage-committed amniotic cells (ACs) can be reprogrammed into ...
ORGANISM(S): Homo sapiens 
2012-10-30 | E-GEOD-40291 | biostudies-arrayexpress
ProteomicsIdentification of proteins precipitated by means of Acyl-RAC
The objective was to perform protein identification by ESI-LC-MSMS on a sample subjected to Acyl-RAC assay in order to study protein palmitoylation. The user transfected human paxillin (mCherry-paxillin-CAIL) into a mouse cell line and performed Acyl-RAC assay. The aim of this analysis was to determ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-30 | PXD023810 | Pride
Paxillin Palmitoylation 3t3-nih 
TranscriptomicsE. coli MG1655Î?rac treated (N340S/G324D Rho) vs control (WT Rho)
Transcription profiling of E. coli MG1655Î?rac, comparing the effect Rho mutants (SBS: N340S, G324D) with WT Rho Organism: Escherichia coli ,Agilent Custom Escherichia coli Gene Expression Microarray 8x15K (AMADID: 020304) designed by Genotypic Technology Private Limited.
ORGANISM(S): Escherichia coli 
2016-03-28 | E-GEOD-77177 | biostudies-arrayexpress
ProteomicsA transcription factor from the cryptic Escherichia coli Rac prophage controls both phage and host operons
Bacterial genomes are shaped by cryptic prophages, which are viral genomes integrated into the bacterial chromosome. Escherichia coli genomes have 10 prophages on average. Though usually inactive, prophage genes can profoundly impact host cell physiology. Among the phage genes in the E. coli chromos...
ORGANISM(S): Escherichia coli 
2025-05-07 | PXD059580 | Pride
Proteomics Escherichia coli Rac prophage tf Ydat locus Dda Putative transcription factors 
TranscriptomicsCharacterization of a P-REX1 gene signature in breast cancer cells
The Rac nucleotide Exchange Factor (Rac-GEF) P-Rex1 is highly expressed in breast cancer, specifically in the luminal subtype, and is an essential mediator of actin cytoskeleton reorganization and cell migratory responses induced by ErbB and other tyrosine-kinase receptors. Heregulin, a growth facto...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-77974 | biostudies-arrayexpress
GenomicsTranscriptional response of Lotus japonicus roots to karrikin1 and rac-GR24
Transcriptional response of Lotus japonicus roots to karrikin1 and rac-GR24
PRJNA671736 | ENA
GenomicsRAC-GEF function as a critical factor in intestinal tumourigenesis
RAC-GEF function as a critical factor in intestinal tumourigenesis
PRJNA445428 | ENA
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