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TranscriptomicsCharacterization of a P-REX1 gene signature in breast cancer cells
The Rac nucleotide Exchange Factor (Rac-GEF) P-Rex1 is highly expressed in breast cancer, specifically in the luminal subtype, and is an essential mediator of actin cytoskeleton reorganization and cell migratory responses induced by ErbB and other tyrosine-kinase receptors. Heregulin, a growth facto...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-77974 | biostudies-arrayexpress
ProteomicsThe Rac-GEF Tiam1 controls integrin-dependent neutrophil responses
Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav and Dock families. In this study, we demonstrate that Tia...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD046791 | Pride
Tiam1 Dock2 Vav Neutrophils Rac Prex1 Rac-gef Small gtpase 
GenomicsRAC-GEF function as a critical factor in intestinal tumourigenesis
RAC-GEF function as a critical factor in intestinal tumourigenesis
PRJNA445428 | ENA
UnknownA RAC-GEF network critical for early intestinal tumourigenesis.
Not available
S-EPMC7782582 | biostudies-literature
UnknownRac GEF Dock4 interacts with cortactin to regulate dendritic spine formation.
Not available
S-EPMC3655820 | biostudies-literature
UnknownPhosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.
Not available
S-EPMC5739283 | biostudies-literature
UnknownP-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity.
Not available
S-EPMC12569377 | biostudies-literature
UnknownCentral role of the exchange factor GEF-H1 in TNF-α-induced sequential activation of Rac, ADAM17/TACE, and RhoA in tubular epithelial cells.
Not available
S-EPMC3608494 | biostudies-literature
UnknownSubtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation.
Not available
S-EPMC4303123 | biostudies-literature
UnknownIdentification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.
Not available
S-EPMC3038344 | biostudies-literature
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