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ProteomicsThe Rac-GEF Tiam1 controls integrin-dependent neutrophil responses
Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav and Dock families. In this study, we demonstrate that Tia...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD046791 | Pride
Tiam1 Dock2 Vav Neutrophils Rac Prex1 Rac-gef Small gtpase 
GenomicsInvestigating TIAM1 in NSCLC (ChIP-Seq)
Investigating TIAM1 in NSCLC (ChIP-Seq)
PRJNA906610 | ENA
GenomicsInvestigating TIAM1 in NSCLC (RNA-Seq)
Investigating TIAM1 in NSCLC (RNA-Seq)
PRJNA906609 | ENA
TranscriptomicsWhole genome microarray of T lymphoma invasion and metastasis (Tiam1) silenced retinoblastoma Y79 cells
We hypothesized that Tiam1 is involved in invassiveness of retinoblastoma. The fuctional role of Tiam1 in cell progression and metastasis was tested by siRNA mediated knockdown of Tiam1 in retinoblastoma Y79 cells. The genes de-regulated in response to Tiam1 knockdown was analysed by cDNA microarray...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-45130 | biostudies-arrayexpress
GenomicsTiam1 methylation by NSD2 promotes Rac1 signaling activation and cancer metastasis
Tiam1 methylation by NSD2 promotes Rac1 signaling activation and cancer metastasis
PRJNA996217 | ENA
TranscriptomicsInvestigating TIAM1 in NSCLC (RNA-Seq)
The T lymphoma invasion and metastasis inducing protein 1 (TIAM1) is a guanine nucleotide exchange factor (GEF) that activates the small GTPase RAC1. We have shown that nuclear TIAM1promotes the migration of NSCLC cells. To investigate the requirement for TIAM1 in regulating gene expression of NSCLC...
ORGANISM(S): Homo sapiens 
2023-09-12 | GSE219028 | GEO
GenomicsInvestigating TIAM1 in NSCLC (ChIP-Seq)
The T lymphoma invasion and metastasis inducing protein 1 (TIAM1) is a guanine nucleotide exchange factor (GEF) that activates the small GTPase RAC1. We have shown that nuclear TIAM1 promotes the migration of NSCLC cells and regulates the expression of adhesion genes as part of a repressive complex....
ORGANISM(S): Homo sapiens 
2023-09-12 | GSE219029 | GEO
GenomicsTiam1 methylation by NSD2 promotes Rac1 signaling activation and cancer metastasis II
Tiam1 methylation by NSD2 promotes Rac1 signaling activation and cancer metastasis II
PRJNA997352 | ENA
TranscriptomicsList of TIAM1 differentially expressed genes in SW620 cells [RNA-seq]
The T lymphoma invasion and metastasis inducing protein 1 (TIAM1) is a guanine nucleotide exchange factor (GEF) that activates the small GTPase RAC1 and regulates a plethora of functions such as cell proliferation, migration, apoptosis and polarity. Recently, we demonstrated that TIAM1 shuttles betw...
ORGANISM(S): Homo sapiens 
2017-04-26 | GSE90491 | GEO
GenomicsThe inhibitory effect of TIAM1 on TAZ transcriptional activity [ChIP-seq]
The T lymphoma invasion and metastasis inducing protein 1 (TIAM1) is a guanine nucleotide exchange factor (GEF) that activates the small GTPase RAC1 and regulates a plethora of functions such as cell proliferation, migration, apoptosis and polarity. Recently, we demonstrated that TIAM1 shuttles betw...
ORGANISM(S): Homo sapiens 
2017-04-26 | GSE90490 | GEO
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