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ProteomicsDextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy
Click chemistry facilitates efficient antibody conjugation to NP surfaces, yet challenges persist when incubating the NPs with culturing medium. Protein corona formation in biological environments may obscure the antibodies, limiting their interactions with T cells. Hence, we conducted proteomics an...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD067738 | Pride
Human serum Dextran nanoparticle 
TranscriptomicsExpression data from Th2 cell of ECM1 KO mice vs WT mice
CD4+ helper T cells are critical for immunological response. Th2 cells, a subset of CD4+ helper T cells, are responsible for asthma and other immune diseases. We found a Th2 secreted protein, ExtraCellular Matrix protein 1 (ECM1), which is highly induced by classic IL-4 signaling pathway during help...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-19707 | biostudies-arrayexpress
ProteomicsRats, Brain, LC-MSMS - iTRAQ-Based Proteomics Analysis Reveals the Effect of Rhubarb in Rats with Ischemic Stroke
In our study, we apply isobaric tag for relative and absolute quantitation (iTRAQ) followed by multidimensional liquid chromatography and tandem MS analysis(LC-MS-MS). The iTRAQ labeling were performed according to the manufacturer's protocol (Applied Biosystems).8 groups of samples were labeled and...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-24 | PXD006437 | Pride
Lc-msms Brain Rats 
UnknownTET2 Regulates 5-Hydroxymethylcytosine Signature and CD4+ T-Cell Balance in Allergic Rhinitis.
Not available
S-EPMC8914607 | biostudies-literature
MetabolomicsA Comprehensive and Ultrasensitive Isotope Calibration Method for Soil Amino Compounds Using Orbitrap Mass Spectrometry
Bound amino compounds (amino acid and amino sugar polymers) comprise a significant proportion (~40%) of soil organic nitrogen and therefore represent an essential source of nitrogen for plant and microbial nutrition. The analysis of their content and isotope enrichment still represents a significant...
2025-06-16 | MTBLS12550 | MetaboLights
UnknownAssociation of TLR4 and Treg in Helicobacter pylori Colonization and Inflammation in Mice.
Not available
S-EPMC4762684 | biostudies-literature
UnknownThe LGALS9/miR-491-5p Axis Regulates CD8<sup>+</sup> T Cell Function and Inhibits the Progression of Gastric Cancer.
Not available
S-EPMC12775568 | biostudies-literature
Proteomicsquantitative proteomic and phosphoproteomic reveal the underlying mechanism of capecitabine's immunosuppressive effect
metronomic doses of CAP were administered to normal mice by gavage, and the spleen was selected for quantitative proteomic and phosphoproteomic analysis.
ORGANISM(S): Mus <genus> 
2021-12-04 | PXD030193 |
TranscriptomicsKlf4
Klf4 is the zinc finger transcription factor indispensable for terminal maturation of epithelial tissues and part of group of proteins for the generation of pluripotent embryonic stem cells from differentiated tissues. No definitive in-vivo-function of Klf4 in the hematopoietic system has been estab...
ORGANISM(S): Mus musculus 
2012-07-30 | E-GEOD-11572 | biostudies-arrayexpress
UnknownMachine learning integrations for development of a T-cell-tolerance derived signature to improve the clinical outcomes and precision treatment of hepatocellular carcinoma.
Not available
S-EPMC9906086 | biostudies-literature
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