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MetabolomicsFasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis

Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable. Harmful use of alcohol is one of the greatest risk factors for de...

2023-05-15 | MTBLS5071 | MetaboLights
Proteomicshuman ESCO2-interacting proteins in response to DNA damage
We used IP-MS to detected the proteins that interact with ESCO2 in response to DNA damage.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD039072 | Pride
Huamn Esco2 Dna damage 
MetabolomicsMulti-kingdom profiling reveals altered gut phage-bacteria-metabolite interactions in MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly linked to gut microbial dysbiosis. To date, most studies have been limited to bacterial taxa, neglecting viruses and fungi, and their interactions. Here we performed shotgun metagenomic and ITS2 sequencing on fecal s...

2026-03-18 | MTBLS14073 | MetaboLights
TranscriptomicsCnot3-dependent mRNA deadenylation safeguards the pluripotent state
Poly(A)-tail length and mRNA deadenylation play important roles in post-transcriptional gene regulation. Here, we report the regulation of mRNA expression, half-life, and polysome association in mouse embryonic stem cells by the Cnot3 subunit in the Ccr4-Not mRNA deadenylase complex. To determine th...
ORGANISM(S): Mus musculus 
2016-08-10 | E-GEOD-84953 | biostudies-arrayexpress
MetabolomicsMechanism of interventional effect and targets of Zhuyu Pill in regulating and suppressing colitis and cholestasis

Zhuyu pill (ZYP) is a traditional Chinese medicine prescription composed of two drugs, Coptis chinensis Franch. and Tetradium ruticarpum (A. Jussieu) T. G. Hartley, and is commonly used in the clinical treatment of diseases of the digestive system. However, the mechanism underly...

2022-11-02 | MTBLS4980 | MetaboLights
ProteomicsQuantitative proteomics and phosphoproteomics of urinary extracellular vesicles define putative diagnostic biosignatures for Parkinson’s disease
Background: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been recognized as genetic risk factors for Parkinson’s disease (PD). However, compared to cancer, fewer genetic mutations contribute to the cause of PD, propelling the search for protein biomarkers for early detection of th...
ORGANISM(S): Homo Sapiens 
2024-11-02 | PXD032175 | panorama
ProteomicsIntegrated Proteomics and Metabolomics Analysis in Pregnant Rat Hippocampus After Circadian Rhythm Inversion
To investigate the changes in proteins, metabolites, and related mechanisms in the Q7 hypothalamus of pregnant rats after circadian rhythm inversion during the whole pregnancy cycle
ORGANISM(S): Rattus Rattus 
2022-06-26 | PXD034926 |
ProteomicsProteomic analyses of plasma-derived exosomes in IgG4-RD and its potential role in B cell differentiation and tissue damage
Objective: This study aimed to investigate plasma exosome profiling of IgG4-RD and its potential role in B cell differentiation and tissue damage. Methods: One hundred untreated IgG4-RD patients and 135 sex, age matched healthy controls (HCs) were enrolled in this study. A combination of liquid chro...
ORGANISM(S): Homo Sapiens 
2020-09-14 | PXD021441 |
Proteomicsimmunoprecipitation-mass spectrometry related to rice stripe virus SP
immunoprecipitation-mass spectrometry related to rice stripe virus SP
ORGANISM(S): Oryza Sativa 
2025-05-07 | PXD063713 |
ProteomicsFecal protein changes in different colorectal diseases
We examined fecal proteins from normal subjects (n=6), patients with inflammatory bowel disease (n=8), patients with colorectal adenoma (n=8), and patients with colorectal cancer (n=14) in the hope of identifying novel fecal protein markers that could be used to identify colorectal diseases.
ORGANISM(S): Homo Sapiens 
2022-12-22 | PXD039089 |
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