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ProteomicsUbiquitin substrates were identified in SILAC-labeled H1299 wild-type and MPND KO cells using LC-MS/MS.
Using H1299 wild-type cells and their MPND-knockout derivatives as research subjects, this project employs Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) for metabolic labeling of the two cell groups. Combined with ubiquitinated peptide-specific enrichment and nano-liquid chromatogra...
ORGANISM(S): Homo sapiens (Human) 
2026-05-15 | PXD074990 | Pride
H1299 Mpnd 
ProteomicsLC-MS analysis of MPND associated complexes in H1299 cells
he Mpr1/Pad1 N-terminal domain-containing protein (MPND) belongs to the JAMM family of deubiquitinases and is ubiquitously expressed across human tissues. However, its role in non-small cell lung cancer (NSCLC) remains unexplored. In this study, we demonstrate that MPND expression is frequently redu...
ORGANISM(S): Homo sapiens (Human) 
2026-05-15 | PXD067575 | Pride
Complexes Mpnd 
MetabolomicsResearch on the quality markers of antioxidant activity of Kai-Xin-San based on spectrum-effect relationship
Kai-Xin-San (KXS) is one of the classic famous traditional Chinese medicine prescriptions for amnesia, which has been applied for thousands of years. Modern pharmacological research has found that KXS has significant therapeutic efficacy on nervous system diseases, which is related to its antioxidan...
2023-12-21 | MTBLS8806 | MetaboLights
TranscriptomicsGenome-scale analysis of DNA methylation in rheumatic heart disease
The aim of the current study is to identify DNA methylation markers associated with rheumatic heart disease with secondary pulmonary arterial hypertension (RHD-PAH). Genome-wide DNA methylation study is performed among 6 RHD-PAH patients and 6 healthy controls using Illumina HumanMethylation 450K ar...
ORGANISM(S): Homo sapiens 
2016-07-06 | E-GEOD-84003 | biostudies-arrayexpress
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