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MetabolomicsSerum metabolomic profiles for distinguishing lung cancer from pulmonary tuberculosis: identification of rapid and noninvasive biomarker

BACKGROUND: Pulmonary tuberculosis (TB) and lung cancer (LC) have similar clinical symptoms and atypical imaging findings which are easily misdiagnosed. There is an urgent need for a noninvasive, rapid and accurate biomarker for distinguishing LC from TB.

METHODS:

2024-01-16 | MTBLS6990 | MetaboLights
ProteomicsS-nitrosocysteine proteomics of Schistosoma japonicum collected from infected mice and rats
Rats and mice were infected with Schistosoma japonicum, and the worms were collected from infected rats and mice. Worms in rats were exposed to high level of NO, while the worms in mice were not. Then a S-nitrosocysteine proteomics of Schistosoma japonicum collected from infected rats and mice was p...
ORGANISM(S): Schistosoma Japonicum 
2024-04-19 | PXD041667 |
MetabolomicsAge-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates.

The incidence of intestinal diseases increases with age, but the regulators of gut aging and the molecules linking gut aging and diseases remain largely unknown. By profiling the transcriptome, proteome, phosphoproteome and metabolome of 104 Macaca fascicularis large intestinal tissues, ...

2023-12-14 | MTBLS7612 | MetaboLights
MetabolomicsDistinct metabolic profiling is correlated with bisexual flowers formation resulting from exogenous ethephon induction in melon (Cucumis melo L.)

Melon (Cucumis melo L.) is an agronomically important vegetable. Most cultivars of melon are andromonoecious and bisexual flowers only emerged from the leaf axil of lateral branches. However, the regulatory mechanism contributing to the occurrence of bisexual flowers were still obscure. ...

2022-03-10 | MTBLS2993 | MetaboLights
MetabolomicsThe effects of different rootstocks on aroma components, activities and genes expression of aroma-related enzymes in oriental melon fruit

Grafting is widely applied in the cultivation of melon. In this study, 'Qinmi No.1' [Cucumis melo L. (QG)] and 'Ribenxuesong' [Cucurbita maxima Duch. (RG)] were used as rootstocks for 'QingxinYangjiaocui' (Cucumis melo L.). The results showed that grafting with...

2023-11-21 | MTBLS8677 | MetaboLights
ProteomicsHSV1 ICP0 associated ubiquitination modulation in N2A neuron cells
Proteome-wide survey of ubiquitination modulation in N2A neuron cells in response to HSV1 ICP0 transfection and HSV1 infection
ORGANISM(S): Homo Sapiens Human Herpesvirus 1 Mus Musculus 
2021-01-17 | PXD019782 |
ProteomicsProteomics reveals the potential mechanism of Mrps35 controlling Listeria intracellular proliferation in macrophages
We performed the comprehensive proteomics to analyze the dynamic expression landscape of wild type and Mrps35 Knockdown Raw264.7 cells by Listeria infection over 6h. Based on the results of mass spectrometry, we presented a wide variety of hypotheses about the mechanism of Mrps35 controlling the Lis...
ORGANISM(S): Mus Musculus 
2020-10-22 | PXD022127 |
ProteomicsMouse Testis IP-MS Analysis of TEX44 Interacting Proteins
Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine ...
ORGANISM(S): Mus Musculus 
2025-02-20 | PXD060989 |
ProteomicsIntegrative omics reveals magnesium deficiency as a driver factor of colorectal cancer
Magnesium (Mg) deficiency is associated with increased risk and malignancy of colorectal cancer (CRC), but the underlying mechanisms remain elusive. In our study, we used genomic, proteomic, and phosphoproteomic data to reveal the effects of low Mg content on genomic instability and tumor metastasis...
ORGANISM(S): Homo Sapiens 
2023-06-05 | PXD042746 |
ProteomicsProteomics data of colorectal cancer
Paired tumor and distant normal tissues from a cohort of 104 colon cancer patients were collected at West China Hospital and snap-frozen in liquid nitrogen. The informed consent forms were signed by the participants or their family members.
ORGANISM(S): Homo Sapiens 
2023-01-11 | PXD039360 |
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