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TranscriptomicsMast cell expression data from murine aryl hydrocarbon receptor (AhR) null, AhR_d and normal control mice
We found that AhR, a unique chemical sensor, is critical in controlling mast cell differentiation, growth and function in vitro and in vivo. This study seeks to further the understanding of the mechanisms of how AhR control mast cell homeostasis. Three different batches of bone marrow derived mast c...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-44715 | biostudies-arrayexpress
ProteomicsStarvation-induced Hsc70 O-GlcNAcylation activates chaperone-mediated autophagy
O-linked β-N-acetylglucosamine (O-GlcNAc) functions as a nutrition rheostat to mediate cellular signaling pathways. It fluctuates in response to various nutritional factors, for instance, glucose. Previous investigations have shown that both glucose surplus and glucose deprivation upregulate O-GlcNA...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD070146 | Pride
Hsc70  o-glcnac  chaperone-mediated autophagy  ataxin-10  ogt 
ProteomicsO-GlcNAcylation of the tumor suppressor LATS1 drives mitotic progression via PLK1
Initially discovered in Drosophila, the Hippo pathway is pivotal for tissue growth and organ homeostasis. Regulated by both extrinsic and intrinsic signals, the Hippo pathway exerts its effect via a core kinase cascade, in which Large tumor suppressor 1 and 2 (LATS1/2) plays a key role. LATS1 has be...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD064782 | Pride
Lats1  hippo  ogt  o-glcnac  plk1 
ProteomicsYEATS2 O-GlcNAcylation Promotes Chromatin Association of the ATAC complex and Lung Cancer Tumorigenesis
The intracellular O-linked N-acetylglucosamine (O-GlcNAc) modification is known to be enriched in the nucleus and in particular on chromatin, but many of its chromatin targets remain to be identified. Herein we demonstrate the O-GlcNAcylation of YEATS Domain Containing 2 (YEATS2), a subunit of the c...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD060970 | Pride
O-glcnac  yeats2  atac  h3k9ac  zzz3 
ProteomicsO-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma
The intracellular O-linked N-acetylglucosamine (O-GlcNAc) glycosylation mediates many signal transduction events and regulates tumorigenesis. Previously the RNA N6-methyladenosine (m6A) reader, YTH (YT521-B homology) domain 2 (YTHDF2), has been shown to be O-GlcNAcylated on Ser-263 during Hepatitis ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD045137 | Pride
O-glcnac  m6a  c-myc  erk  lung carcinoma 
ProteomicsO-GlcNAc crosstalks with ADP-ribosylation via PARG
O-GlcNAc glycosylation is a prevalent protein post-translational modification (PTM) that occurs intracellularly. Previous investigations have demonstrated that O-GlcNAcylation crosstalks with phosphorylation and ubiquitination, but it is unclear whether it interplays with other PTMs. Here we studied...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041119 | Pride
Hepatocellular carcinoma Poly(adp-ribosyl)ation O-glcnacylation Parg C-myc 
ProteomicsO-Fucosylation of CPN20 by SPINDLY Derepresses Abscisic Acid Signaling during Seed Germination and Seedling Development--Partial Submission
We utilized ETD (Electron Transfer Dissociation)-MS/MS analysis to identify O-fucosylation sites in ectopically expressed CPN20 in mammalian cells and Arabidopsis.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-02-17 | PXD027272 | Pride
O-fucosylation Etd Lc-ms/ms Cpn20 
UnknownGenome-Wide Linkage Mapping of QTL for Yield Components, Plant Height and Yield-Related Physiological Traits in the Chinese Wheat Cross Zhou 8425B/Chinese Spring.
Not available
S-EPMC4683206 | biostudies-literature
UnknownChanges in circulating Foxp3(+) regulatory T cells and interleukin-17-producing T helper cells during HBV-related acute-on-chronic liver failure.
Not available
S-EPMC4093705 | biostudies-literature
UnknownThe gut microbiota improves reproductive dysfunction in obese mice by suppressing the NLRP3/ASC/caspase-1 axis.
Not available
S-EPMC11552480 | biostudies-literature
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