Sort   by:  
 Page size 
TranscriptomicsExpression profiling in primary embryonic fibroblasts deficient for the N-terminal truncation of Lats1
Lats1 and Lats2 are the mediators of the Hippo pathway that regulates tissue growth and proliferation. Lats1 and Lats2 kinases share 85% sequence identity in the kinase domain. However, their non-kinase regions at the N-terminus are distinct except for Lats conserved domain 1 (LCD1) and LCD2, sugges...
ORGANISM(S): Mus musculus 
2012-12-17 | E-GEOD-37871 | biostudies-arrayexpress
ProteomicsInteraction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP dependent manner
Metastatic malignant melanoma is the deadliest skin cancer type, and it is characterized by its high resistance to apoptosis. The main driving mutations in melanoma cause hyperactivation of genes within the ERK pathway, with BRAF mutations being the most frequent ones, followed by NRAS, NF1 and MEK ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-18 | PXD032781 | Pride
Mst2 Apoptosis Lats1 Smac Hippo Iap Melanoma 
Proteomicsphospho-proteomic data on the LATS1 interactome from cells treated with two proapoptotic signals: FAS and etoposide
Using this approach, we obtained phospho-proteomic data on the LATS1 interactome from cells treated with two proapoptotic signals: FAS and etoposide, which both activate LATS kinase activity [28].To identify the LATS1 interactome we transiently expressed GFP-LATS1 in HeLa cells, immunoprecipitated G...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018903 | Pride
Human Lats1 Hela 
ProteomicsTargeted analysis of PTPN14, YAP1, LATS1 and GFP SH-tagged pulldown
Targeted analysis of YAP1, LATS1 and PTPN14 interactome
ORGANISM(S): Homo sapiens (Human) 
2023-03-04 | PXD032221 | Pride
Yap1 Lats1 Ptpn14 Apms 
ProteomicsO-GlcNAcylation of the tumor suppressor LATS1 drives mitotic progression via PLK1
Initially discovered in Drosophila, the Hippo pathway is pivotal for tissue growth and organ homeostasis. Regulated by both extrinsic and intrinsic signals, the Hippo pathway exerts its effect via a core kinase cascade, in which Large tumor suppressor 1 and 2 (LATS1/2) plays a key role. LATS1 has be...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD064782 | Pride
Lats1  hippo  ogt  o-glcnac  plk1 
TranscriptomicsGenome-wide analysis of gene expression using in vitro cultured control and Lats1/2 deficient hepatoblasts [RNA-Seq]
RNA-sequencing results with in vitro cultured control and Lats1/2 deficient hepatoblasts, in vitro differentiated control and Lats1/2 deficient hepatocytes and biliary epithelial cells To investigate changes in gene expression by loss of Lats1 and Lats2 during hepatocyte or biliary epithelial cell d...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-71873 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human MCF10A cells expressing YAP to identify the targets of the YAP oncogene
YAP is an oncogene and an inducer of Epithelial-to-Mesenchymal Transition (EMT). We used microarrays to detail the global program of gene expression to identify YAP target genes. PUBLICATION ABSTRACT:; The Hippo pathway defines a novel signaling cascade regulating cell proliferation and survival in...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-10196 | biostudies-arrayexpress
GenomicsLats1/2 depletion in male sertoli cells
Lats1/2 depletion in male sertoli cells
PRJNA1017416 | ENA
GenomicsRole of endothelial Lats1 and Lats2 in endothelial response to flow
Role of endothelial Lats1 and Lats2 in endothelial response to flow
PRJNA1269309 | ENA
TranscriptomicsRNA-seq of ATM-knockout human embryonic stem-cells (h-pES10) treated with the LATS1/2 inhibitor Lats-IN-1 (TRULI) for 24 h against untreated cells
LATS1/2 are canonical Hippo signaling pathway components. Our genome-wide screen indicated a synthetic viable effect of Hippo pathway inhibition in ATM-depleted human embryonic and neural progenitor cells. This experiment was designed in order to get mechanistic insights regarding the molecular effe...
ORGANISM(S): Homo sapiens 
2024-01-10 | E-MTAB-12600 | biostudies-arrayexpress
Sort   by:  
 Page size