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TranscriptomicsExpression data from Mst knockout embryoid bodies and wild type embryoid bodies
Mst1/Mst2 are central components of Hippo pathway. We examined the role of Mst1/Mst2 in ES cell differentiation. In this data set, we include expression data from day 4 and day 8 Mst1/Mst2 knockout ES cell formed embryoid bodies and wild type embryoid body controls. total 4 samples.
ORGANISM(S): Mus musculus 
2014-01-02 | E-GEOD-50219 | biostudies-arrayexpress
ProteomicsDynamic MST2 interactome profiling across MYCN-dependent states in neuroblastoma
Abstract Neuroblastoma (NB) is the most common extracranial solid tumour in children. Half of high-risk NB cases are driven by MYCN amplification, a critical oncogene that is challenging to target therapeutically. To identify novel therapeutic entry points, we investigated the Hippo pathway kinase M...
ORGANISM(S): Homo sapiens (Human) 
2026-09-16 | PXD078418 | Pride
Mst2 Neuroblastoma Mycn-dependent Interactome Proteomics 
ProteomicsInteraction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP dependent manner
Metastatic malignant melanoma is the deadliest skin cancer type, and it is characterized by its high resistance to apoptosis. The main driving mutations in melanoma cause hyperactivation of genes within the ERK pathway, with BRAF mutations being the most frequent ones, followed by NRAS, NF1 and MEK ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-18 | PXD032781 | Pride
Mst2 Apoptosis Lats1 Smac Hippo Iap Melanoma 
ProteomicsThe histone acetyltransferase Mst2 protects active chromatin from epigenetic silencing by acetylating the ubiquitin ligase Brl1
Faithful propagation of functionally distinct chromatin states is crucial for maintaining cellular identity, and its breakdown can lead to diseases such as cancer. Whereas mechanisms that sustain repressed states have been intensely studied, regulatory circuits that protect active chromatin from ina...
ORGANISM(S): Schizosaccharomyces pombe 
2017-06-28 | PXD005714 | Pride
Mst2 Acetylome Ms3 Acetylation Brl1 Heterochromatin 
GenomicsEffect of inactivation of Mst1 and Mst2 in the mouse adrenal cortex
Effect of inactivation of Mst1 and Mst2 in the mouse adrenal cortex
PRJNA768884 | ENA
ProteomicsCharacterization of Affinity Purifications of full length MST2 and exon 7 deleted MST2 by mass spectrometry
Hippo is a tumor suppressor pathway and is related to the regulation of cell proliferation, apoptosis, organ size and tumorigenesis. In mammals, the Hippo pathway core is composed of 4 serine-threonine kinases: Mammalian Ste-20-like Kinase 1 and 2 (MST1 and MST2) and large suppressive tumor 1 and 2 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-29 | MSV000089341 | MassIVE
TranscriptomicsRNA-seq analysis of Mst1/2 deleted bronchiolar epithelial cells from adult mouse lungs
Mst1 and Mst2 were conditionally deleted from non-ciliated bronchiolar epithelial cells in the mature lung. Bronchiolar epithelial cells from control and Mst1/2 deleted mice were isolated by cell sorting and used for RNA-seq analysis. Scgb1a1-rtTA/tetO-Cre/Mst1;2-flx/flx (Mst1/2 D/D) mice were gene...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-61627 | biostudies-arrayexpress
TranscriptomicsThe tumor suppressor Rassf1a prevents mouse liver tumorigenesis and regulates levels of the oncogenic kinase Tbk1 and of beta tubulin gene expression in the liver
The tumor suppressor gene RASSF1A (Ras association domain family protein 1A) coding for a microtubule stabilizing protein is epigenetically silenced in most human cancers. As a binding partner of the kinases MST1 and MST2, the mammalian orthologues of the Drosophila Hippo kinase, RASSF1A is a potent...
ORGANISM(S): Mus musculus 
2016-05-31 | E-GEOD-73911 | biostudies-arrayexpress
UnknownSARAH Domain-Mediated MST2-RASSF Dimeric Interactions.
Not available
S-EPMC5055338 | biostudies-literature
UnknownH-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization.
Not available
S-EPMC4915977 | biostudies-literature
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