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GenomicsRetrotransposon-based profiling of mammalian epigenomes: DNA methylation of IAP LTRs in embryonic stem, somatic and cancer cells
In this study, we analyzed the DNA methylation levels of 4799 IAP LTRs in three murine cell types: AB2.2 ES cells, somatic cells and a neuroblastoma cell line Neuro2A. According to the results, half of the IAP LTR retrotransposons show constant methylation patterns between the three cell types where...
ORGANISM(S): Mus musculus 
2015-06-15 | E-GEOD-60007 | biostudies-arrayexpress
TranscriptomicsEffects of physiological and synthetic IAP antagonism on c-IAP dependent signaling
Cellular inhibitor of apoptosis proteins 1 and 2 (c-IAP1/2) play central roles in signal transduction mediated by numerous receptors that participate in inflammatory and immune responses. In certain pathways, such as activation of NF-kB, their degradation is a major regulatory event and is physiolog...
ORGANISM(S): Homo sapiens 
2015-02-09 | E-GEOD-64927 | biostudies-arrayexpress
TranscriptomicsMicroarray-based global mapping of integration sites of retrotransposon, intracisternal A-particle, in mouse genome
Mammalian genomes have evolutionary harbored numerous mobile elements, a part of which are still active and evoke genomic instability. Their movement and positional diversity occasionally result in phenotypic changes and variation by causing altered expression and disruption of neighboring genes in...
ORGANISM(S): Mus musculus 
2008-05-03 | E-GEOD-9572 | biostudies-arrayexpress
GenomicsPseudomonas sp. IAP-CY TE4608
Pseudomonas sp. IAP-CY TE4608 Genome sequencing
PRJNA1142995 | ENA
ProteomicsIAP-binding intrabodies for concurrent degradation of proto-oncogenes and toggling cell death modalities
Single domain antibodies or antibody mimetics, such as monobodies, can be engineered to degrade undruggable targets via fusion to ubiquitin E3 ligases. In this study we developed multi-targeting biodegrader intrabodies by harnessing an inhibitor of apoptosis (IAP) E3 ligase RING domain, or the IAP-b...
ORGANISM(S): Homo sapiens (Human) 
2026-03-03 | PXD061128 | Pride
Intrabody Cancer Iap protein Drugs Tnf Baf Biodegrader Ciap1 Xiap Bioprotac Smac mimetic Ring Protac Swi/snf Intracellular antibody E3 ligase 
ProteomicsInteraction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP dependent manner
Metastatic malignant melanoma is the deadliest skin cancer type, and it is characterized by its high resistance to apoptosis. The main driving mutations in melanoma cause hyperactivation of genes within the ERK pathway, with BRAF mutations being the most frequent ones, followed by NRAS, NF1 and MEK ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-18 | PXD032781 | Pride
Mst2 Apoptosis Lats1 Smac Hippo Iap Melanoma 
UnknownIntestinal alkaline phosphatase (IAP, IAP Enhancer) attenuates intestinal inflammation and alleviates insulin resistance.
Not available
S-EPMC9359302 | biostudies-literature
UnknownReaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition.
Not available
S-EPMC2713440 | biostudies-literature
TranscriptomicsEffects of physiological and synthetic IAP antagonism on c-IAP dependent signaling
Cellular inhibitor of apoptosis proteins 1 and 2 (c-IAP1/2) play central roles in signal transduction mediated by numerous receptors that participate in inflammatory and immune responses. In certain pathways, such as activation of NF-kB, their degradation is a major regulatory event and is physiolog...
ORGANISM(S): Homo sapiens 
2015-02-09 | GSE64927 | GEO
GenomicsInter-strain epigenomic profiling reveals a candidate IAP master copy in C3H mice
Inter-strain epigenomic profiling reveals a candidate IAP master copy in C3H mice
PRJNA638636 | ENA
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