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TranscriptomicsExpression data from MDA-MB-231 parental and xenograft tumor cells treated with Smac mimetic SM-164.
Small-molecule Smac mimetics target inhibitor of apoptosis (IAP) proteins to induce TNFα-dependent apoptosis in cancer cells and several Smac mimetics have been advanced into clinical development as a new class of anticancer drugs. However, preclinical studies have shown that only a small subset of...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-33827 | biostudies-arrayexpress
ProteomicsInteraction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP dependent manner
Metastatic malignant melanoma is the deadliest skin cancer type, and it is characterized by its high resistance to apoptosis. The main driving mutations in melanoma cause hyperactivation of genes within the ERK pathway, with BRAF mutations being the most frequent ones, followed by NRAS, NF1 and MEK ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-18 | PXD032781 | Pride
Mst2 Apoptosis Lats1 Smac Hippo Iap Melanoma 
ProteomicsStructural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6
Certain Inhibitors of apoptosis (IAP) family members are sentinel proteins preventing untimely cell death by inhibiting caspases. Antagonists including second mitochondria-derived activator of caspase (SMAC) regulate IAPs, driving cell death. Baculoviral IAP repeat-containing protein 6 (BIRC6), a gi...
ORGANISM(S): Homo sapiens (Human) 
2023-03-08 | PXD039954 | Pride
Ap-ms Birc6 Structural biology Cell death Ubiquitomics Biochemistry 
TranscriptomicsMicroarray analysis of in-vitro differentiated murine Th17 cells in the presence of the smac mimetic AT406, or DMSO as control, and undifferentiated naive CD4 T cells.
Transcriptome analysis to investigate the effects of the smac mimetic AT406 on the differentiation of murine Th17 cells compared to DMSO controls, and to investigate the transriptome of murine Th17 cells compared to control undifferentiated naive CD4 T cells.
ORGANISM(S): Mus musculus 
2019-08-15 | E-MTAB-7894 | biostudies-arrayexpress
ProteomicsStructural basis for how sMAC is packaged for clearance
In this study, we used bottom-up proteomics and cross-linking MS (XL-MS) to study the composition and structure of soluble membrane attack complex (sMAC). For bottom-up proteomics sMAC was digested using trypsin and analyzed on Orbitrap Fusion Lumos. For the cross-linking analysis sMAC was cross-lin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-25 | MSV000087092 | MassIVE
GenomicsSMAC mimetics induce human macrophages to phagocytose live cancer cells
SMAC mimetics induce human macrophages to phagocytose live cancer cells
PRJNA1190496 | ENA
GenomicsIncreasing MG1-Mediated Death in HIV-Infected Cells with SMAC Mimetics
Increasing MG1-Mediated Death in HIV-Infected Cells with SMAC Mimetics
PRJNA1167326 | ENA
ProteomicsSMAC mimetics regulate Th17 differentiation, function and physiology via the non-canonical NFkB pathway
TMT 10-plex proteome analysis of murine CD4+ T cells differentiated towards a Th17 lineage in the presence of a SMAC mimetic
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000082955 | MassIVE
GenomicsThe influence of the Smac mimetic BV6 on the rhabdomyosarcoma cell line RH30
The influence of the Smac mimetic BV6 on the rhabdomyosarcoma cell line RH30
PRJNA928379 | ENA
TranscriptomicsmRNAseq of human sputum macrophages and alveolar-like monocyte-derived macrophages of healthy controls and NSAID-exacerbated respiratory disease (N-ERD) patients
NSAID-exacerbated respiratory disease (N-ERD) represents a particularly severe endotype of chronic rhinosinusitis with nasal polyps (CRSwNP), which affects around 10-16% of CRSwNP patients. N-ERD is characterized by severe and refractory nasal polyposis, bronchial asthma and intolerance to non-stero...
ORGANISM(S): Homo sapiens 
2020-06-30 | E-MTAB-7965 | biostudies-arrayexpress
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