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TranscriptomicsInactivation of CDK2 is synthetic lethal to MYCN-overexpressing cancer cells
Two genes have a synthetic lethal relationship when silencing or inhibition of one gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells wit...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-16480 | biostudies-arrayexpress
ProteomicsDynamic MST2 interactome profiling across MYCN-dependent states in neuroblastoma
Abstract Neuroblastoma (NB) is the most common extracranial solid tumour in children. Half of high-risk NB cases are driven by MYCN amplification, a critical oncogene that is challenging to target therapeutically. To identify novel therapeutic entry points, we investigated the Hippo pathway kinase M...
ORGANISM(S): Homo sapiens (Human) 
2026-09-16 | PXD078418 | Pride
Mst2 Neuroblastoma Mycn-dependent Interactome Proteomics 
GenomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma
Enhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma
PRJNA318035 | ENA
TranscriptomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma [ATAC-seq]
In neuroblastoma, amplification of the oncogenic basic helix-loop-helix (bHLH) transcription factor (TF) MYCN is the defining prognosticator of high-risk disease, occurs in one-third of neuroblastoma, and drastically reduces overall survival rates1,2. As a proto-oncogene, targeted MYCN overexpressio...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-80152 | biostudies-arrayexpress
UnknownEnhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma.
Not available
S-EPMC6310397 | biostudies-literature
GenomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma [ChIP-seq]
In neuroblastoma, amplification of the oncogenic basic helix-loop-helix (bHLH) transcription factor (TF) MYCN is the defining prognosticator of high-risk disease, occurs in one-third of neuroblastoma, and drastically reduces overall survival rates. As a proto-oncogene, targeted MYCN overexpression i...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-80151 | biostudies-arrayexpress
UnknownCyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
Not available
S-EPMC4645454 | biostudies-literature
TranscriptomicsEnhancer invasion shapes MYCN dependent transcriptional amplification in neuroblastoma
Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and transcriptional landscape of MYCN perturbation in neuroblastoma. At oncogenic levels, MYCN associates with E-box binding motif...
ORGANISM(S): Homo sapiens Mus musculus 
2018-01-29 | GSE80154 | GEO
UnknownMRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors.
Not available
S-EPMC6117286 | biostudies-literature
GenomicsPharmacological blockade of MYCN in neuroblastoma using orally-bioavailable CDK inhibitors reveals an approach widely applicable to Myc-dependent cancers
Pharmacological blockade of MYCN in neuroblastoma using orally-bioavailable CDK inhibitors reveals an approach widely applicable to Myc-dependent cancers
PRJNA419129 | ENA
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