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ProteomicsIonizable polymeric micelles (IPMs) for efficient siRNA delivery
Lipid nanoparticles (LNPs) are widely used for nucleic acid delivery but face challenges like limited targeting and accelerated blood clearance. We design three ionizable oligo-mers (IOs) that, with PLA-PEG, form Ionizable Polymeric Micelles (IPMs), a potential siRNA delivery system, which can achie...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-21 | PXD057444 | Pride
Hsp47 Protein corona Hmgb1 Hepatic fibrosis Fibroblast activation protein inhibitor (fapi) Nucleic acid delivery Ionizable polymeric micelles (ipms) Hepatic stellate cells 
ProteomicsTMT-Based Quantitative Proteomic Analysis of Intestinal Or-ganoids Infected by Listeria monocytogenes with Different Virulence
L. monocytogenes consisting of 13 serotypes, is an opportunistic food-borne pathogen that causes different host reactions to depend on its serotypes. In this study, highly toxic L. monocytogenes 10403s resulted in more severe infections and lower survival rates. Additionally, to investigate the remo...
ORGANISM(S): Mus Musculus 
PXD034151 |
ProteomicsPDZ domain-containing adaptor protein GIPC1 interacts with the SR-B1 and modulates its expression and lipid transport function
PDZ family protein GIPC1 physically interacts with SR-B1 and regulates SR-B1 expression by promoting SR-B1 protein stability.
ORGANISM(S): Mus Musculus 
2021-03-09 | PXD024595 |
ProteomicsChromatin-associated OGT promotes hepatocellular carcinoma malignancy via activating ZNF263
OGT, the only facilitator which attaches the monosaccharide to many oncogenic factors or tumor suppressors, has been suggested to play an influential role in tumorigenesis and metastasis of HCC. OGT interactome analyses indicates that disordered OGT may serve as a hub protein to activate the buildin...
ORGANISM(S): Homo Sapiens 
2023-01-12 | PXD039365 |
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